BACKGROUND: The relationship between asbestos and stomach cancer is not well understood because of small number of cases. This study aimed to determine the incidence and mortality of stomach cancer among workers exposed to asbestos based on a systematic review and meta-analysis approach. METHODS: Relevant English electronic databases were systematically searched for published studies characterizing the risk of developing stomach cancer as a result of asbestos exposure. Standardized mortality rate (SMR) for stomach cancer with its 95% confidence interval (CI) was pooled using a fixed-/random-effect model in STATA. RESULTS: A total of 32 independent studies were included for the analysis. The overall SMR for stomach cancer was 1.19 (95% CI 1.06-1.34), with a moderate degree of heterogeneity across the studies (I(2) = 37.6%, P = 0.011). Being male, exposure to crocidolite, miners, studies conducted in Europe and Oceania, and long study follow-up (≥ 25 years) all contribute to significantly higher SMR. Significant publication bias was observed. CONCLUSION: Elevated risk of stomach cancer mortality was evidenced among workers exposed to crocidolite, especially male miners.
BACKGROUND: The relationship between asbestos and stomach cancer is not well understood because of small number of cases. This study aimed to determine the incidence and mortality of stomach cancer among workers exposed to asbestos based on a systematic review and meta-analysis approach. METHODS: Relevant English electronic databases were systematically searched for published studies characterizing the risk of developing stomach cancer as a result of asbestos exposure. Standardized mortality rate (SMR) for stomach cancer with its 95% confidence interval (CI) was pooled using a fixed-/random-effect model in STATA. RESULTS: A total of 32 independent studies were included for the analysis. The overall SMR for stomach cancer was 1.19 (95% CI 1.06-1.34), with a moderate degree of heterogeneity across the studies (I(2) = 37.6%, P = 0.011). Being male, exposure to crocidolite, miners, studies conducted in Europe and Oceania, and long study follow-up (≥ 25 years) all contribute to significantly higher SMR. Significant publication bias was observed. CONCLUSION: Elevated risk of stomach cancer mortality was evidenced among workers exposed to crocidolite, especially male miners.
Authors: Timothy Driscoll; Deborah Imel Nelson; Kyle Steenland; James Leigh; Marisol Concha-Barrientos; Marilyn Fingerhut; Annette Prüss-Ustün Journal: Am J Ind Med Date: 2005-12 Impact factor: 2.214
Authors: Beate Pesch; Dirk Taeger; Georg Johnen; Isabelle M Gross; Daniel G Weber; Monika Gube; Alice Müller-Lux; Evelyn Heinze; Thorsten Wiethege; Volker Neumann; Andrea Tannapfel; Hans-Jürgen Raithel; Thomas Brüning; Thomas Kraus Journal: Int J Hyg Environ Health Date: 2009-09-26 Impact factor: 5.840
Authors: E Pira; C Pelucchi; L Buffoni; A Palmas; M Turbiglio; E Negri; P G Piolatto; C La Vecchia Journal: Br J Cancer Date: 2005-02-14 Impact factor: 7.640