Rui Zhou, Huadong Zhou, Li Rui, Jianzhong Xu1. 1. Department of Orthopedics, the Orthopedic Surgery Center of Chinese PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, P.R. China. zhouhuad@163.com.
Abstract
OBJECTIVE: The aim of this study was to analyze the relationship between low bone mineral density (BMD) and conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia in a Chinese cohort. METHODS: Men and women (n=946) aged 60-75 underwent a dual X-ray absorptiometry (DXA) study of the lumbar spine and hip and were followed annually for 5 years. Their cognitive and functional status were assessed using the Chinese version of the Mini-Mental State Examination (MMSE) and an assessment of the instrumental activities of daily living (ADL). RESULTS: There was a positive relationship between osteoporosis and a decline in cognition and function (P<0.001) based on MMSE and ADL scores. The subjects with BMD values in the lowest quartile had a 2-fold increased risk of AD conversion compared with the controls. These results suggest that severe BMD loss is associated with an increased risk of AD conversion in both women and men. CONCLUSIONS: Osteoporosis was associated with an increased risk of incident AD dementia. Additionally, low BMD at baseline was associated with an increased risk of AD in both women and men.
OBJECTIVE: The aim of this study was to analyze the relationship between low bone mineral density (BMD) and conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia in a Chinese cohort. METHODS:Men and women (n=946) aged 60-75 underwent a dual X-ray absorptiometry (DXA) study of the lumbar spine and hip and were followed annually for 5 years. Their cognitive and functional status were assessed using the Chinese version of the Mini-Mental State Examination (MMSE) and an assessment of the instrumental activities of daily living (ADL). RESULTS: There was a positive relationship between osteoporosis and a decline in cognition and function (P<0.001) based on MMSE and ADL scores. The subjects with BMD values in the lowest quartile had a 2-fold increased risk of AD conversion compared with the controls. These results suggest that severe BMD loss is associated with an increased risk of AD conversion in both women and men. CONCLUSIONS:Osteoporosis was associated with an increased risk of incident AD dementia. Additionally, low BMD at baseline was associated with an increased risk of AD in both women and men.
Authors: Ryan D Ross; Raj C Shah; Sue Leurgans; Teodoro Bottiglieri; Robert S Wilson; Dale Rick Sumner Journal: J Gerontol A Biol Sci Med Sci Date: 2018-11-10 Impact factor: 6.053
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Authors: Sarah Westwood; Alison L Baird; Abdul Hye; Nicholas J Ashton; Alejo J Nevado-Holgado; Sneha N Anand; Benjamine Liu; Danielle Newby; Chantal Bazenet; Steven J Kiddle; Malcolm Ward; Ben Newton; Keyur Desai; Cristina Tan Hehir; Michelle Zanette; Daniela Galimberti; Lucilla Parnetti; Alberto Lleó; Susan Baker; Vaibhav A Narayan; Wiesje M van der Flier; Philip Scheltens; Charlotte E Teunissen; Pieter Jelle Visser; Simon Lovestone Journal: Front Aging Neurosci Date: 2018-12-11 Impact factor: 5.750