| Literature DB >> 25115523 |
Xin Yang1, Hongsheng Ouyang, Fuwang Chen, Teng Ma, Meichen Dong, Fei Wang, Daxing Pang, Zhiyuan Peng, Linzhu Ren.
Abstract
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) pathway is an important metabolic route that is present in almost every organism. However, whether HMGCR affects the expression of interferon (IFN)-responsive genes is unclear. In the present study, expression levels of IFN-responsive genes were monitored by real time polymerase chain reaction and enzyme-linked immunosorbent assay. The results showed that expression levels of IFN-responsive genes were significantly increased in HMGCR-downregulated cells and HMGCR inhibitor-treated cells, indicating that inhibition of HMGCR activates the expression of IFN-responsive genes. The result in this study will provide new insight into the role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in antiviral research.Entities:
Keywords: 3-hydroxy-3-methylglutaryl-coenzyme A reduc-tase; gene expression; inhibition; interferon; responsive
Mesh：
Substances：
Year: 2014 PMID： 25115523 DOI： 10.1111/1440-1681.12299
Source DB: PubMed Journal: Clin Exp Pharmacol Physiol ISSN： 0305-1870 Impact factor: 2.557