Literature DB >> 25114374

Cardiac left ventricular thrombus in protein C deficiency.

Feridoun Sabzi1, Reza Faraji1.   

Abstract

We report an exceptional case of, 33-year-old woman presenting with, dyspnoea and chest pain, Cardio respiratory sign and symptom related to diastolic dysfunction caused by mass effect of thrombosis on diastolic filling of left ventricule (LV). The common aetiologies of these devastating complication results in thrombophillia diagnosis, and echocardioghraphy showed a large mass in left ventricular cavity. In laboratory exam, protein C-S deficiency was confirmed however, others related test of thrombophillia were negative. The patient underwent cardiopulmonary bypass with thrombosis extraction and her sign and symptom, recovered uneventfully. This case report illustrates an exceedingly rare case of thrombophilia-induced left ventricular clot formation.

Entities:  

Keywords:  Chest pain; dysfunction; dyspnoea; left ventricule; protein C deficiency; thrombosis

Year:  2014        PMID: 25114374      PMCID: PMC4124552          DOI: 10.4103/0300-1652.137229

Source DB:  PubMed          Journal:  Niger Med J        ISSN: 0300-1652


  7 in total

Review 1.  Regulation of blood coagulation.

Authors:  C T Esmon
Journal:  Biochim Biophys Acta       Date:  2000-03-07

Review 2.  Hereditary protein C deficiency: a review of the genetics, clinical presentation, diagnosis and treatment.

Authors:  R A Marlar; S Mastovich
Journal:  Blood Coagul Fibrinolysis       Date:  1990-08       Impact factor: 1.276

3.  Left ventricular thrombosis due to acquired protein C deficiency diagnosed by two-dimensional echocardiography.

Authors:  S Ozkutlu; N Ozbarlas; M Saraçlar; F Oztunç
Journal:  Jpn Heart J       Date:  1992-03

4.  Clinical, imaging, and pathological characteristics of left ventricular thrombus: a comparison of contrast-enhanced magnetic resonance imaging, transthoracic echocardiography, and transesophageal echocardiography with surgical or pathological validation.

Authors:  Monvadi B Srichai; Chelif Junor; L Leonardo Rodriguez; Arthur E Stillman; Richard A Grimm; Michael L Lieber; Joan A Weaver; Nicholas G Smedira; Richard D White
Journal:  Am Heart J       Date:  2006-07       Impact factor: 4.749

5.  Alteration of fibrin network by activated protein C.

Authors:  A Gruber; E Mori; G J del Zoppo; L Waxman; J H Griffin
Journal:  Blood       Date:  1994-05-01       Impact factor: 22.113

6.  Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn.

Authors:  U Seligsohn; A Berger; M Abend; L Rubin; D Attias; A Zivelin; S I Rapaport
Journal:  N Engl J Med       Date:  1984-03-01       Impact factor: 91.245

Review 7.  Left ventricular thrombus formation after acute myocardial infarction.

Authors:  Ronak Delewi; Felix Zijlstra; Jan J Piek
Journal:  Heart       Date:  2012-12       Impact factor: 5.994

  7 in total

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