Literature DB >> 25113561

Plakophilin-2 promotes activation of epidermal growth factor receptor.

Andrius Kazlauskas1.   

Abstract

While growth factor-driven dimerization of receptor tyrosine kinases (RTKs) is a simple and intuitive mechanism of activating RTKs, K.-I. Arimoto et al. (Mol. Cell. Biol. 34:3843-3854, 2014, doi:10.1128/MCB.00758-14) describe a novel means of promoting the activity of RTKs. Namely, plakophilin-2 (PKP2) associates with the epidermal growth factor receptor (EGFR) and enhances its ligand-dependent and ligand-independent activity. This discovery suggests that antagonizing PKP2 may be a new therapeutic opportunity to combat tumors in which activation of EGFR contributes to pathogenesis.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25113561      PMCID： PMC4187716          DOI： 10.1128/MCB.00968-14

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  10 in total

1.  Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis.

Authors:  Silvia Svegliati Baroni; Mariarosaria Santillo; Federica Bevilacqua; Michele Luchetti; Tatiana Spadoni; Matteo Mancini; Paolo Fraticelli; Paola Sambo; Ada Funaro; Andrius Kazlauskas; Enrico V Avvedimento; Armando Gabrielli
Journal:  N Engl J Med       Date:  2006-06-22       Impact factor: 91.245

2.  The juxtamembrane region of the EGF receptor functions as an activation domain.

Authors:  Monica Red Brewer; Sung Hee Choi; Diego Alvarado; Katarina Moravcevic; Ambra Pozzi; Mark A Lemmon; Graham Carpenter
Journal:  Mol Cell       Date:  2009-06-26       Impact factor: 17.970

3.  Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation.

Authors:  Y Yarden; J Schlessinger
Journal:  Biochemistry       Date:  1987-03-10       Impact factor: 3.162

4.  Plakophilin-2 promotes tumor development by enhancing ligand-dependent and -independent epidermal growth factor receptor dimerization and activation.

Authors:  Kei-ichiro Arimoto; Christoph Burkart; Ming Yan; Dan Ran; Stephanie Weng; Dong-Er Zhang
Journal:  Mol Cell Biol       Date:  2014-08-11       Impact factor: 4.272

5.  Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers.

Authors:  M C Maa; T H Leu; D J McCarley; R C Schatzman; S J Parsons
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

6.  MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

Authors:  Jeffrey A Engelman; Kreshnik Zejnullahu; Tetsuya Mitsudomi; Youngchul Song; Courtney Hyland; Joon Oh Park; Neal Lindeman; Christopher-Michael Gale; Xiaojun Zhao; James Christensen; Takayuki Kosaka; Alison J Holmes; Andrew M Rogers; Federico Cappuzzo; Tony Mok; Charles Lee; Bruce E Johnson; Lewis C Cantley; Pasi A Jänne
Journal:  Science       Date:  2007-04-26       Impact factor: 47.728

7.  Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells.

Authors:  Hetian Lei; Andrius Kazlauskas
Journal:  J Biol Chem       Date:  2009-01-06       Impact factor: 5.157

8.  Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein.

Authors:  L Petti; L A Nilson; D DiMaio
Journal:  EMBO J       Date:  1991-04       Impact factor: 11.598

9.  Architecture and membrane interactions of the EGF receptor.

Authors:  Anton Arkhipov; Yibing Shan; Rahul Das; Nicholas F Endres; Michael P Eastwood; David E Wemmer; John Kuriyan; David E Shaw
Journal:  Cell       Date:  2013-01-31       Impact factor: 41.582

10.  Conformational coupling across the plasma membrane in activation of the EGF receptor.

Authors:  Nicholas F Endres; Rahul Das; Adam W Smith; Anton Arkhipov; Erika Kovacs; Yongjian Huang; Jeffrey G Pelton; Yibing Shan; David E Shaw; David E Wemmer; Jay T Groves; John Kuriyan
Journal:  Cell       Date:  2013-01-31       Impact factor: 41.582
  10 in total
  5 in total

1.  Plakophilin-2 induced EGFR phosphorylation: a focus on the intracellular activators of EGFR.

Authors:  Kei-Ichiro Arimoto; Stephanie Weng; Dong-Er Zhang
Journal:  Receptors Clin Investig       Date:  2014

2.  Analysis of porcine body size variation using re-sequencing data of miniature and large pigs.

Authors:  C Reimer; C-J Rubin; A R Sharifi; N-T Ha; S Weigend; K-H Waldmann; O Distl; S D Pant; M Fredholm; M Schlather; H Simianer
Journal:  BMC Genomics       Date:  2018-09-19       Impact factor: 3.969

3.  Increased expression of plakophilin 3 is associated with poor prognosis in ovarian cancer.

Authors:  Hua Qian; Donglan Yuan; Jingjing Bao; Fuxing Liu; Wenyan Zhang; Xumei Yang; Gaohua Han; Junxing Huang; Haihui Sheng; Hong Yu
Journal:  Medicine (Baltimore)       Date:  2019-03       Impact factor: 1.817

4.  LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.

Authors:  Wei Tang; Di Wang; Lianqi Shao; Xiaobai Liu; Jian Zheng; Yixue Xue; Xuelei Ruan; Chunqing Yang; Libo Liu; Jun Ma; Zhen Li; Yunhui Liu
Journal:  Mol Ther Nucleic Acids       Date:  2019-11-16       Impact factor: 8.886

5.  Plakophilin-2 Promotes Lung Adenocarcinoma Development via Enhancing Focal Adhesion and Epithelial-Mesenchymal Transition.

Authors:  Yang Wu; Lu Liu; Xiaoyu Shen; Wenjing Liu; Rui Ma
Journal:  Cancer Manag Res       Date:  2021-01-22       Impact factor: 3.989
  5 in total

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