Literature DB >> 25112953

2'-Deoxyuridine conjugated with a reactive monobenzocyclooctyne as a DNA building block for copper-free click-type postsynthetic modification of DNA.

Claudia Stubinitzky1, Gergely B Cserép, Effi Bätzner, Péter Kele, Hans-Achim Wagenknecht.   

Abstract

The carboxymethylmonobenzocyclooctyne group attached to the 5-position of a 2'-deoxyuridine in DNA allows rapid and efficient copper-free postsynthetic modification as demonstrated with a far-red emitting fluorescent azide probe. Upon labeling strong fluorescence intensity enhancement is observed.

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Year:  2014        PMID： 25112953     DOI： 10.1039/c4cc02855d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Post-synthesis DNA modifications using a trans-cyclooctene click handle.

Authors:  Ke Wang; Danzhu Wang; Kaili Ji; Weixuan Chen; Yueqin Zheng; Chaofeng Dai; Binghe Wang
Journal:  Org Biomol Chem       Date:  2015-01-21       Impact factor: 3.876

Review 2.  Covalent labeling of nucleic acids.

Authors:  Nils Klöcker; Florian P Weissenboeck; Andrea Rentmeister
Journal:  Chem Soc Rev       Date:  2020-10-21       Impact factor: 54.564

3.  Site-specific labeling of RNA by combining genetic alphabet expansion transcription and copper-free click chemistry.

Authors:  Tatsuhiko Someya; Ami Ando; Michiko Kimoto; Ichiro Hirao
Journal:  Nucleic Acids Res       Date:  2015-06-29       Impact factor: 16.971
  3 in total

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