Literature DB >> 25112803

Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia: risk factor and potential therapeutic target?

Michela Faggioni1, Christian van der Werf2, Bjorn C Knollmann3.   

Abstract

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited heart rhythm disorder characterized by the occurrence of potentially life-threatening polymorphic ventricular tachyarrhythmias in conditions of physical or emotional stress. The underlying cause is a dysregulation in intracellular Ca handling due to mutations in the sarcoplasmic reticulum Ca release unit. Recent experimental work suggests that sinus bradycardia, which is sometimes observed in CPVT patients, may be another primary defect caused by CPVT mutations. Herein, we review the pathophysiology of CPVT and discuss the role of sinus node dysfunction as a modulator of arrhythmia risk and potential therapeutic target.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25112803      PMCID： PMC4171185          DOI： 10.1016/j.tcm.2014.07.001

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  38 in total

1.  Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients.

Authors:  Michela Faggioni; Hyun Seok Hwang; Christian van der Werf; Ineke Nederend; Prince J Kannankeril; Arthur A M Wilde; Björn C Knollmann
Journal:  Circ Res       Date:  2013-01-07       Impact factor: 17.367

2.  Familial evaluation in catecholaminergic polymorphic ventricular tachycardia: disease penetrance and expression in cardiac ryanodine receptor mutation-carrying relatives.

Authors:  Christian van der Werf; Ineke Nederend; Nynke Hofman; Nan van Geloven; Corné Ebink; Ingrid M E Frohn-Mulder; A Marco W Alings; Hans A Bosker; Frank A Bracke; Freek van den Heuvel; Reinier A Waalewijn; Hennie Bikker; J Peter van Tintelen; Zahurul A Bhuiyan; Maarten P van den Berg; Arthur A M Wilde
Journal:  Circ Arrhythm Electrophysiol       Date:  2012-07-10

3.  Cardioversion of intraatrial reentrant tachycardia using rate response.

Authors:  Vincent C Thomas; Ian H Law; William N Evans
Journal:  Pacing Clin Electrophysiol       Date:  2012-04-22       Impact factor: 1.976

Review 4.  Therapeutic approach for patients with catecholaminergic polymorphic ventricular tachycardia: state of the art and future developments.

Authors:  Christian van der Werf; Aeilko H Zwinderman; Arthur A M Wilde
Journal:  Europace       Date:  2011-09-04       Impact factor: 5.214

5.  Vagal reflexes following an exercise stress test: a simple clinical tool for gene-specific risk stratification in the long QT syndrome.

Authors:  Lia Crotti; Carla Spazzolini; Alessandra P Porretta; Federica Dagradi; Erika Taravelli; Barbara Petracci; Alessandro Vicentini; Matteo Pedrazzini; Maria Teresa La Rovere; Emilio Vanoli; Althea Goosen; Marshall Heradien; Alfred L George; Paul A Brink; Peter J Schwartz
Journal:  J Am Coll Cardiol       Date:  2012-11-14       Impact factor: 24.094

6.  Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death.

Authors:  Mette Nyegaard; Michael T Overgaard; Mads T Søndergaard; Marta Vranas; Elijah R Behr; Lasse L Hildebrandt; Jacob Lund; Paula L Hedley; A John Camm; Göran Wettrell; Inger Fosdal; Michael Christiansen; Anders D Børglum
Journal:  Am J Hum Genet       Date:  2012-10-05       Impact factor: 11.025

Review 7.  Triadin regulates cardiac muscle couplon structure and microdomain Ca(2+) signalling: a path towards ventricular arrhythmias.

Authors:  Nagesh Chopra; Björn C Knollmann
Journal:  Cardiovasc Res       Date:  2013-02-08       Impact factor: 10.787

8.  Efficacy of implantable cardioverter defibrillators in young patients with catecholaminergic polymorphic ventricular tachycardia: success depends on substrate.

Authors:  Christina Y Miyake; Gregory Webster; Richard J Czosek; Michal J Kantoch; Anne M Dubin; Kishor Avasarala; Joseph Atallah
Journal:  Circ Arrhythm Electrophysiol       Date:  2013-05-11

9.  Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human.

Authors:  Nathalie Roux-Buisson; Marine Cacheux; Anne Fourest-Lieuvin; Jeremy Fauconnier; Julie Brocard; Isabelle Denjoy; Philippe Durand; Pascale Guicheney; Florence Kyndt; Antoine Leenhardt; Hervé Le Marec; Vincent Lucet; Philippe Mabo; Vincent Probst; Nicole Monnier; Pierre F Ray; Elodie Santoni; Pauline Trémeaux; Alain Lacampagne; Julien Fauré; Joël Lunardi; Isabelle Marty
Journal:  Hum Mol Genet       Date:  2012-03-14       Impact factor: 6.150

10.  Follow-up with exercise test of effort-induced ventricular arrhythmias linked to ryanodine receptor type 2 gene mutations.

Authors:  Alexandros Klavdios Steriotis; Andrea Nava; Alessandra Rampazzo; Cristina Basso; Gaetano Thiene; Luciano Daliento; Antonio Franco Folino; Ilaria Rigato; Elisa Mazzotti; Giorgia Beffagna; Elisa Carturan; Domenico Corrado; Barbara Bauce
Journal:  Am J Cardiol       Date:  2012-01-03       Impact factor: 2.778
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  9 in total

1.  Chronotropic incompetence as a risk predictor in children and young adults with catecholaminergic polymorphic ventricular tachycardia.

Authors:  Sonia Franciosi; Thomas M Roston; Frances K G Perry; Bjorn C Knollmann; Prince J Kannankeril; Shubhayan Sanatani
Journal:  J Cardiovasc Electrophysiol       Date:  2019-07-11

2.  Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.

Authors:  Vassilios J Bezzerides; Ana Caballero; Suya Wang; Yulan Ai; Robyn J Hylind; Fujian Lu; Danielle A Heims-Waldron; Kristina D Chambers; Donghui Zhang; Dominic J Abrams; William T Pu
Journal:  Circulation       Date:  2019-06-03       Impact factor: 29.690

3.  STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.

Authors:  Hengtao Zhang; Albert Y Sun; Jong J Kim; Victoria Graham; Elizabeth A Finch; Igor Nepliouev; Guiling Zhao; Tianyu Li; W J Lederer; Jonathan A Stiber; Geoffrey S Pitt; Nenad Bursac; Paul B Rosenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2015-09-30       Impact factor: 11.205

Review 4.  Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia.

Authors:  Matthew J Wleklinski; Prince J Kannankeril; Bjӧrn C Knollmann
Journal:  J Physiol       Date:  2020-04-27       Impact factor: 5.182

Review 5.  Atrial arrhythmias in inherited arrhythmogenic disorders.

Authors:  Can Hasdemir
Journal:  J Arrhythm       Date:  2016-02-09

6.  SK4 K+ channels are therapeutic targets for the treatment of cardiac arrhythmias.

Authors:  Shiraz Haron-Khun; David Weisbrod; Hanna Bueno; Dor Yadin; Joachim Behar; Asher Peretz; Ofer Binah; Edith Hochhauser; Michael Eldar; Yael Yaniv; Michael Arad; Bernard Attali
Journal:  EMBO Mol Med       Date:  2017-04       Impact factor: 12.137

Review 7.  Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review).

Authors:  Gary Tse; Tong Liu; Ka Hou Christien Li; Victoria Laxton; Andy On-Tik Wong; Yin Wah Fiona Chan; Wendy Keung; Camie W Y Chan; Ronald A Li
Journal:  Int J Mol Med       Date:  2017-02-06       Impact factor: 4.101

8.  Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia.

Authors:  Prince J Kannankeril; M Benjamin Shoemaker; Kathryn A Gayle; Darlene Fountain; Dan M Roden; Bjorn C Knollmann
Journal:  Europace       Date:  2020-04-01       Impact factor: 5.214

Review 9.  Catecholaminergic polymorphic ventricular tachycardia: An exciting new era.

Authors:  Shashank P Behere; Steven N Weindling
Journal:  Ann Pediatr Cardiol       Date:  2016 May-Aug
  9 in total

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