Literature DB >> 25111817

Genetic architecture of type 2 diabetes.

Kazuo Hara1, Nobuhiro Shojima1, Jun Hosoe1, Takashi Kadowaki2.   

Abstract

Genome-wide association studies (GWAS) have identified over 70 loci associated with type 2 diabetes (T2D). Most genetic variants associated with T2D are common variants with modest effects on T2D and are shared with major ancestry groups. To what extent the genetic component of T2D can be explained by common variants relies upon the shape of the genetic architecture of T2D. Fine mapping utilizing populations with different patterns of linkage disequilibrium and functional annotation derived from experiments in relevant tissues are mandatory to track down causal variants responsible for the pathogenesis of T2D.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Genome-wide association studies; Linkage disequilibrium; Risk allele frequency; Single nucleotide polymorphism; Type 2 diabetes mellitus

Mesh：

Year:  2014        PMID： 25111817     DOI： 10.1016/j.bbrc.2014.08.012

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

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