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Literature DB >> 25111671

The roles of microphthalmia-associated transcription factor and pigmentation in melanoma.

Abstract

MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma.

Entities: Chemical Disease Gene Mutation Species

Keywords: MITF; Melanocyte; Melanoma; Pigmentation

Mesh：

Substances：

Year: 2014 PMID： 25111671 PMCID： PMC4336945 DOI： 10.1016/j.abb.2014.07.019

Source DB: PubMed Journal: Arch Biochem Biophys ISSN： 0003-9861 Impact factor: 4.013

73 in total

1. Pax3 functions at a nodal point in melanocyte stem cell differentiation.

Authors: Deborah Lang; Min Min Lu; Li Huang; Kurt A Engleka; Maozhen Zhang; Emily Y Chu; Shari Lipner; Arthur Skoultchi; Sarah E Millar; Jonathan A Epstein
Journal: Nature Date: 2005-02-24 Impact factor: 49.962

2. Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner.

Authors: Hideki Murakami; Heinz Arnheiter
Journal: Pigment Cell Res Date: 2005-08

3. Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform.

Authors: Christine L Hershey; David E Fisher
Journal: Gene Date: 2005-02-28 Impact factor: 3.688

4. Distinct sets of genetic alterations in melanoma.

Authors: John A Curtin; Jane Fridlyand; Toshiro Kageshita; Hetal N Patel; Klaus J Busam; Heinz Kutzner; Kwang-Hyun Cho; Setsuya Aiba; Eva-Bettina Bröcker; Philip E LeBoit; Dan Pinkel; Boris C Bastian
Journal: N Engl J Med Date: 2005-11-17 Impact factor: 91.245

5. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.

Authors: Levi A Garraway; Hans R Widlund; Mark A Rubin; Gad Getz; Aaron J Berger; Sridhar Ramaswamy; Rameen Beroukhim; Danny A Milner; Scott R Granter; Jinyan Du; Charles Lee; Stephan N Wagner; Cheng Li; Todd R Golub; David L Rimm; Matthew L Meyerson; David E Fisher; William R Sellers
Journal: Nature Date: 2005-07-07 Impact factor: 49.962

6. Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.

Authors: Keith W Vance; Suzanne Carreira; Gerald Brosch; Colin R Goding
Journal: Cancer Res Date: 2005-03-15 Impact factor: 12.701

7. BRAFE600-associated senescence-like cell cycle arrest of human naevi.

Authors: Chrysiis Michaloglou; Liesbeth C W Vredeveld; Maria S Soengas; Christophe Denoyelle; Thomas Kuilman; Chantal M A M van der Horst; Donné M Majoor; Jerry W Shay; Wolter J Mooi; Daniel S Peeper
Journal: Nature Date: 2005-08-04 Impact factor: 49.962

8. Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation.

Authors: Claudia Wellbrock; Richard Marais
Journal: J Cell Biol Date: 2005-08-29 Impact factor: 10.539

9. Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells.

Authors: Roser Buscà; Edurne Berra; Cédric Gaggioli; Mehdi Khaled; Karine Bille; Barbara Marchetti; Raphaël Thyss; Giorgos Fitsialos; Lionel Larribère; Corine Bertolotto; Thierry Virolle; Pascal Barbry; Jacques Pouysségur; Gilles Ponzio; Robert Ballotti
Journal: J Cell Biol Date: 2005-06-27 Impact factor: 10.539

10. Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

Authors: Claudia Wellbrock; Sareena Rana; Hugh Paterson; Helen Pickersgill; Thijn Brummelkamp; Richard Marais
Journal: PLoS One Date: 2008-07-16 Impact factor: 3.240

50 in total

1. High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma.

Authors: Philip Eliades; Brian J Abraham; Zhenyu Ji; David M Miller; Camilla L Christensen; Nicholas Kwiatkowski; Raj Kumar; Ching Ni Njauw; Michael Taylor; Benchun Miao; Tinghu Zhang; Kwok-Kin Wong; Nathanael S Gray; Richard A Young; Hensin Tsao
Journal: J Invest Dermatol Date: 2018-02-08 Impact factor: 8.551

2. Altered Notch Signaling in Dowling-Degos Disease: Additional Mutations in POGLUT1 and Further Insights into Disease Pathogenesis.

Authors: Damian J Ralser; Hideyuki Takeuchi; Günter Fritz; F Buket Basmanav; Maike Effern; Sugirthan Sivalingam; Laila El-Shabrawi-Caelen; Ece N Degirmentepe; Emek Kocatürk; Manuraj Singh; Nina Booken; Natalia M K Spierings; Viktor Schnabel; Andre Heineke; Jana Knuever; Sabrina Wolf; Maria Wehner; Michael Tronnier; Martin Leverkus; Iliana Tantcheva-Poór; Jörg Wenzel; Vinzenz Oji; Cristina Has; Michael Hölzel; Jorge Frank; Robert S Haltiwanger; Regina C Betz
Journal: J Invest Dermatol Date: 2018-11-09 Impact factor: 8.551

3. Priorities and trends in the study of proteins in eye research, 1924-2014.

Authors: Richard D Semba; Maggie Lam; Kai Sun; Pingbo Zhang; Debra A Schaumberg; Luigi Ferrucci; Peipei Ping; Jennifer E Van Eyk
Journal: Proteomics Clin Appl Date: 2015-09-16 Impact factor: 3.494

4. FBXW7 regulates a mitochondrial transcription program by modulating MITF.

Authors: Franco Abbate; Brateil Badal; Karen Mendelson; Iraz T Aydin; Madhavika N Serasinghe; Ramiz Iqbal; Jarvier N Mohammed; Alexander Solovyov; Benjamin D Greenbaum; Jerry E Chipuk; Julide T Celebi
Journal: Pigment Cell Melanoma Res Date: 2018-04-29 Impact factor: 4.693