Leslie Z Sokolow1, Allison L Naleway2, De-Kun Li3, Pat Shifflett4, Sue Reynolds5, Michelle L Henninger2, Jeannette R Ferber6, Roxana Odouli6, Stephanie A Irving2, Mark G Thompson5. 1. Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA; Battelle, Atlanta, GA. Electronic address: lsokolow@cdc.gov. 2. Center for Health Research, Kaiser Permanente Northwest, Portland, OR. 3. Division of Research, Kaiser Foundation Research Institute, Oakland, CA; Department of Health Research and Policy, School of Medicine, Stanford University, Palo Alto, CA. 4. Abt Associates, Inc, Cambridge, MA. 5. Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA. 6. Division of Research, Kaiser Foundation Research Institute, Oakland, CA.
Abstract
OBJECTIVE: The objective of the study was to identify characteristics of influenza illness contrasted with noninfluenza acute respiratory illness (ARI) in pregnant women. STUDY DESIGN: ARI among pregnant women was identified through daily surveillance during 2 influenza seasons (2010-2012). Within 8 days of illness onset, nasopharyngeal swabs were collected, and an interview was conducted for symptoms and other characteristics. A follow-up telephone interview was conducted 1-2 weeks later, and medical records were extracted. Severity of illness was evaluated by self-assessment of 12 illness symptoms, subjective ratings of overall impairment, highest reported temperature, illness duration, and medical utilization. RESULTS: Of 292 pregnant women with ARI, 100 tested positive for influenza viruses. Women with influenza illnesses reported higher symptom severity than those with noninfluenza ARI (median score, 18 vs 16 of 36; P < .05) and were more likely to report severe subjective feverishness (18% vs 5%; P < .001), myalgia (28% vs 14%; P < .005), cough (46% vs 30%; P < .01), and chills (25% vs 13%; P < .01). More influenza illnesses were associated with fever greater than 38.9°C (20% vs 5%; P < .001) and higher subjective impairment (mean score, 5.9 vs 4.8; P < .001). Differences in overall symptom severity, fever, cough, chills, early health care-seeking behavior, and impairment remained significant in multivariate models after adjusting for study site, season, age, vaccination status, and number of days since illness onset. CONCLUSION: Influenza had a greater negative impact on pregnant women than noninfluenza ARIs, as indicated by symptom severity and greater likelihood of elevated temperature. These results highlight the importance of preventing and treating influenza illnesses in pregnant women.
OBJECTIVE: The objective of the study was to identify characteristics of influenza illness contrasted with noninfluenza acute respiratory illness (ARI) in pregnant women. STUDY DESIGN: ARI among pregnant women was identified through daily surveillance during 2 influenza seasons (2010-2012). Within 8 days of illness onset, nasopharyngeal swabs were collected, and an interview was conducted for symptoms and other characteristics. A follow-up telephone interview was conducted 1-2 weeks later, and medical records were extracted. Severity of illness was evaluated by self-assessment of 12 illness symptoms, subjective ratings of overall impairment, highest reported temperature, illness duration, and medical utilization. RESULTS: Of 292 pregnant women with ARI, 100 tested positive for influenza viruses. Women with influenza illnesses reported higher symptom severity than those with noninfluenza ARI (median score, 18 vs 16 of 36; P < .05) and were more likely to report severe subjective feverishness (18% vs 5%; P < .001), myalgia (28% vs 14%; P < .005), cough (46% vs 30%; P < .01), and chills (25% vs 13%; P < .01). More influenza illnesses were associated with fever greater than 38.9°C (20% vs 5%; P < .001) and higher subjective impairment (mean score, 5.9 vs 4.8; P < .001). Differences in overall symptom severity, fever, cough, chills, early health care-seeking behavior, and impairment remained significant in multivariate models after adjusting for study site, season, age, vaccination status, and number of days since illness onset. CONCLUSION: Influenza had a greater negative impact on pregnant women than noninfluenza ARIs, as indicated by symptom severity and greater likelihood of elevated temperature. These results highlight the importance of preventing and treating influenza illnesses in pregnant women.
Authors: Jack A Panapasa; Rebecca J Cox; Kristin G I Mohn; Lara A Aqrawi; Karl A Brokstad Journal: Hum Vaccin Immunother Date: 2015 Impact factor: 3.452
Authors: Mark G Thompson; Jeannette R Ferber; Roxana Odouli; Donna David; Pat Shifflett; Jennifer K Meece; Allison L Naleway; Sam Bozeman; Sarah M Spencer; Alicia M Fry; De-Kun Li Journal: Influenza Other Respir Viruses Date: 2015-05 Impact factor: 4.380
Authors: Mark G Thompson; De-Kun Li; Allison L Naleway; Jeannette R Ferber; Michelle L Henninger; Pat Shifflett; Leslie Z Sokolow; Roxana Odouli; Tia L Kauffman; Rebecca V Fink; Joanna Bulkley; Janet D Cragan; Sam Bozeman Journal: BMC Pregnancy Childbirth Date: 2019-05-08 Impact factor: 3.007