| Literature DB >> 25111443 |
James Y Hamilton1, Nicole Hauser, David Sarlah, Erick M Carreira.
Abstract
An enantioselective allyl-allylsilane cross-coupling involving racemic branched allylic alcohols and allylsilanes is reported. An iridium-(P,olefin) phosphoramidite complex enables the transformation with high regio- and stereoselectivity under operationally simple conditions. The utility of the coupling is demonstrated in a concise catalytic, enantioselective synthesis of a pyrethroid insecticide protrifenbute.Entities:
Keywords: 1,5-diene; allylic substitution; allylsilane; enantioselectivity; iridium
Year: 2014 PMID： 25111443 DOI： 10.1002/anie.201406077
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336