Literature DB >> 25110620

Dementia in MS complicated by coexistent Alzheimer disease: Diagnosis premortem and postmortem.

Eoin P Flanagan1, David S Knopman1, B Mark Keegan1.   

Abstract

Distinguishing dementia due to multiple sclerosis (MS) from that of an accompanying neurodegenerative dementia coexisting with MS has been difficult. The recent introduction of Alzheimer disease (AD) biomarkers of amyloid-β and neuronal degeneration has improved diagnosis of AD premortem. We describe 3 patients with MS with coexisting AD, 1 diagnosed at autopsy before AD biomarkers were available and 2 diagnosed premortem by decreased CSF amyloid-β1-42/tau index, MRI, and 18F-flourodeoxyglucose-PET patterns. AD biomarkers may be of diagnostic value in selected patients with severe dementia and MS.

Entities:  

Year:  2014        PMID： 25110620      PMCID： PMC4121466          DOI： 10.1212/CPJ.0000000000000030

Source DB:  PubMed          Journal:  Neurol Clin Pract        ISSN： 2163-0402


  10 in total

1.  The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

Authors:  Guy M McKhann; David S Knopman; Howard Chertkow; Bradley T Hyman; Clifford R Jack; Claudia H Kawas; William E Klunk; Walter J Koroshetz; Jennifer J Manly; Richard Mayeux; Richard C Mohs; John C Morris; Martin N Rossor; Philip Scheltens; Maria C Carrillo; Bill Thies; Sandra Weintraub; Creighton H Phelps
Journal:  Alzheimers Dement       Date:  2011-04-21       Impact factor: 21.566

2.  Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis.

Authors:  L B Krupp; C Christodoulou; P Melville; W F Scherl; L-Y Pai; L R Muenz; D He; R H B Benedict; A Goodman; S Rizvi; S R Schwid; B Weinstock-Guttman; H J Westervelt; H Wishart
Journal:  Neurology       Date:  2011-04-26       Impact factor: 9.910

Review 3.  Clinical practice. Early Alzheimer's disease.

Authors:  Richard Mayeux
Journal:  N Engl J Med       Date:  2010-06-10       Impact factor: 91.245

Review 4.  Cognitive dysfunctions in multiple sclerosis--a "multiple disconnection syndrome"?

Authors:  Pasquale Calabrese; Iris Katharina Penner
Journal:  J Neurol       Date:  2007-05       Impact factor: 4.849

5.  Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome.

Authors:  D T Okuda; E M Mowry; A Beheshtian; E Waubant; S E Baranzini; D S Goodin; S L Hauser; D Pelletier
Journal:  Neurology       Date:  2008-12-10       Impact factor: 9.910

6.  Multiple sclerosis with predominant, severe cognitive impairment.

Authors:  Nathan P Staff; Claudia F Lucchinetti; B Mark Keegan
Journal:  Arch Neurol       Date:  2009-09

7.  Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS.

Authors:  M Blinkenberg; K Rune; C V Jensen; M Ravnborg; S Kyllingsbaek; S Holm; O B Paulson; P S Sørensen
Journal:  Neurology       Date:  2000-02-08       Impact factor: 9.910

8.  Inflammatory cortical demyelination in early multiple sclerosis.

Authors:  Claudia F Lucchinetti; Bogdan F G Popescu; Reem F Bunyan; Natalia M Moll; Shanu F Roemer; Hans Lassmann; Wolfgang Brück; Joseph E Parisi; Bernd W Scheithauer; Caterina Giannini; Stephen D Weigand; Jay Mandrekar; Richard M Ransohoff
Journal:  N Engl J Med       Date:  2011-12-08       Impact factor: 91.245

9.  The short test of mental status. Correlations with standardized psychometric testing.

Authors:  E Kokmen; G E Smith; R C Petersen; E Tangalos; R C Ivnik
Journal:  Arch Neurol       Date:  1991-07

10.  Cognitive presentation of multiple sclerosis: evidence for a cortical variant.

Authors:  M Zarei; S Chandran; A Compston; J Hodges
Journal:  J Neurol Neurosurg Psychiatry       Date:  2003-07       Impact factor: 10.154
  10 in total
  6 in total

1.  Diagnosis of coexistent neurodegenerative dementias in multiple sclerosis.

Authors:  Diana P Londoño; Kogulavadanan Arumaithurai; Eleni Constantopoulos; Michael R Basso; R Ross Reichard; Eoin P Flanagan; B Mark Keegan
Journal:  Brain Commun       Date:  2022-06-22

Review 2.  Cognitive Decline in Older People with Multiple Sclerosis-A Narrative Review of the Literature.

Authors:  Hsueh-Sheng Chiang; Alka Khera; Barbara E Stopschinski; Olaf Stuve; John Hart; Brendan Kelley; Trung Nguyen
Journal:  Geriatrics (Basel)       Date:  2022-06-05

Review 3.  Impact of Pharmacotherapy on Cognitive Dysfunction in Patients with Multiple Sclerosis.

Authors:  Shumita Roy; Ralph H B Benedict; Allison S Drake; Bianca Weinstock-Guttman
Journal:  CNS Drugs       Date:  2016-03       Impact factor: 5.749

Review 4.  A Clinical Approach to the Differential Diagnosis of Multiple Sclerosis.

Authors:  Michel Toledano; Brian G Weinshenker; Andrew J Solomon
Journal:  Curr Neurol Neurosci Rep       Date:  2015-08       Impact factor: 6.030

5.  Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice.

Authors:  Junjun Sun; Hong Zhou; Feng Bai; Qingguo Ren; Zhijun Zhang
Journal:  Oncotarget       Date:  2016-05-24

6.  Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis.

Authors:  Burcu Zeydan; Val J Lowe; Ross R Reichard; Scott A Przybelski; Timothy G Lesnick; Christopher G Schwarz; Matthew L Senjem; Jeffrey L Gunter; Joseph E Parisi; Mary M Machulda; Prashanthi Vemuri; Michelle M Mielke; David S Knopman; Ronald C Petersen; Clifford R Jack; Orhun H Kantarci; Kejal Kantarci
Journal:  Ann Neurol       Date:  2020-02-08       Impact factor: 10.422
  6 in total

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