Literature DB >> 25110450

Little girl who conquered the "ALPPS''.

Albert Chan1, Patrick H Y Chung1, Ronnie T P Poon1.   

Abstract

An insufficient future liver remnant (FLR) is associated with post-hepatectomy liver failure. Associating liver partition and portal vein ligation for stage hepatectomy (ALPPS) has been shown to be effective for the induction of rapid FLR hypertrophy so as to improve the resectability in patients with insufficient FLR. We hereby report our experience of this novel approach for a 6-year-old patient with hepatoblastoma. Computed tomography showed a hepatoblastoma measuring 12.5 cm × 9.9 cm × 11.7 cm in the right liver (Couinaud segment IV, V and VIII). Volumetric assessment of the FLR i.e., left lateral section was 112.6 mL i.e., 21.2% of the estimated total liver volume. In view of the small-for-size FLR, ALPPS was contemplated. An anterior approach was adopted for the in-situ parenchymal split without mobilisation of the right liver. FLR volumetry on the seventh postoperative day was 160.7 mL, which represented a 46.1% gain in volume, and a FLR/ESLV ratio of 30.2%. A right trisectionectomy was performed on the eighth postoperative day. Postoperative recovery was uneventful. Patient was discharged on day 16 after the first operation. To our knowledge, this was the first report that showed the applicability of ALPPS to a paediatric patient.

Entities:  

Keywords:  Associating liver partition and portal vein ligation for stage hepatectomy; Hepatectomy; Hepatoblastoma; In-situ split; Portal vein

Mesh:

Year:  2014        PMID: 25110450      PMCID: PMC4123352          DOI: 10.3748/wjg.v20.i29.10208

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN: 1007-9327            Impact factor:   5.742


  11 in total

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Review 4.  Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy: a systematic review.

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Review 5.  ALPPS Procedure for Extended Liver Resections: A Single Centre Experience and a Systematic Review.

Authors:  Marco Vivarelli; Paolo Vincenzi; Roberto Montalti; Giammarco Fava; Marcello Tavio; Martina Coletta; Andrea Vecchi; Daniele Nicolini; Andrea Agostini; Emad Ali Ahmed; Andrea Giovagnoni; Federico Mocchegiani
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