| Literature DB >> 25110090 |
Yu V Nesterova1, T N Povet'yeva, N I Suslov, G N Zyuz'kov, S V Pushkarskii, S G Aksinenko, E E Schultz, S S Kravtsova, A V Krapivin.
Abstract
We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene alkaloids of different structure. The antinociceptive effect of atisine alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via opioid receptor modulation.Entities:
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Year: 2014 PMID： 25110090 DOI： 10.1007/s10517-014-2598-6
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804