Literature DB >> 2511006

Autoregulation of fos: the dyad symmetry element as the major target of repression.

H König1, H Ponta, U Rahmsdorf, M Büscher, A Schönthal, H J Rahmsdorf, P Herrlich.   

Abstract

Fos and Jun co-operatively repress the fos promoter. Removal of all putative Fos/Jun binding sites from the fos promoter neither obliterates the repression by Fos/Jun in transient cotransfection experiments in NIH3T3 cells nor the turn-off kinetics of serum-induced fos expression in stably transfected NIH3T3 cells. The dyad symmetry element (DSE) suffices to subject a promoter to this type of repression. However, one of the putative Fos/Jun binding sites (-292 to -299 and thus located immediately adjacent to the DSE), determines the very low level of basal expression.

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Year:  1989        PMID： 2511006      PMCID： PMC401256          DOI： 10.1002/j.1460-2075.1989.tb08394.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  49 in total

1.  The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter.

Authors:  P E Shaw; H Schröter; A Nordheim
Journal:  Cell       Date:  1989-02-24       Impact factor: 41.582

2.  Hepatocyte-specific promoter element HP1 of the Xenopus albumin gene interacts with transcriptional factors of mammalian hepatocytes.

Authors:  M Schorpp; W Kugler; U Wagner; G U Ryffel
Journal:  J Mol Biol       Date:  1988-07-20       Impact factor: 5.469

3.  Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3' AU-rich sequences.

Authors:  T Wilson; R Treisman
Journal:  Nature       Date:  1988-11-24       Impact factor: 49.962

4.  A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

Authors:  T W Hai; F Liu; E A Allegretto; M Karin; M R Green
Journal:  Genes Dev       Date:  1988-10       Impact factor: 11.361

5.  Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

Authors:  M Büscher; H J Rahmsdorf; M Litfin; M Karin; P Herrlich
Journal:  Oncogene       Date:  1988-09       Impact factor: 9.867

6.  Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

Authors:  T M Fisch; R Prywes; M C Simon; R G Roeder
Journal:  Genes Dev       Date:  1989-02       Impact factor: 11.361

7.  The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation.

Authors:  M Schuermann; M Neuberg; J B Hunter; T Jenuwein; R P Ryseck; R Bravo; R Müller
Journal:  Cell       Date:  1989-02-10       Impact factor: 41.582

8.  Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos.

Authors:  P Chavrier; U Janssen-Timmen; M G Mattéi; M Zerial; R Bravo; P Charnay
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

9.  An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate.

Authors:  T M Fisch; R Prywes; R G Roeder
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

10.  Fos C-terminal mutations block down-regulation of c-fos transcription following serum stimulation.

Authors:  T Wilson; R Treisman
Journal:  EMBO J       Date:  1988-12-20       Impact factor: 11.598
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  69 in total

1.  Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1.

Authors:  U Müller; T Kleinberger; T Shenk
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

2.  Negative autoregulation of the neu gene is mediated by a novel enhancer.

Authors:  X Y Zhao; M C Hung
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

3.  Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.

Authors:  B E Pearson; H P Nasheuer; T S Wang
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

4.  Promoter function and structure of the growth factor-inducible immediate early gene cyr61.

Authors:  B V Latinkic; T P O'Brien; L F Lau
Journal:  Nucleic Acids Res       Date:  1991-06-25       Impact factor: 16.971

Review 5.  Fos-jun and the primary genomic response in the nervous system. Possible physiological role and pathophysiological significance.

Authors:  J P Doucet; S P Squinto; N G Bazan
Journal:  Mol Neurobiol       Date:  1990 Spring-Summer       Impact factor: 5.590

6.  Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element.

Authors:  R M Attar; M Z Gilman
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

7.  Negative regulation of the BZLF1 promoter of Epstein-Barr virus.

Authors:  E A Montalvo; Y Shi; T E Shenk; A J Levine
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

8.  A new cAMP response element in the transcribed region of the human c-fos gene.

Authors:  E Härtig; I F Loncarević; M Büscher; P Herrlich; H J Rahmsdorf
Journal:  Nucleic Acids Res       Date:  1991-08-11       Impact factor: 16.971

9.  Antisense rescue defines specialized and generalized functional domains for c-Fos protein.

Authors:  J T Holt
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

10.  Upstream regions of the c-jun promoter regulate phorbol ester-induced transcription in U937 leukemic cells.

Authors:  T Unlap; C C Franklin; F Wagner; A S Kraft
Journal:  Nucleic Acids Res       Date:  1992-02-25       Impact factor: 16.971
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