Literature DB >> 25109998

Physiological roles of the pantothenate kinases.

Lorraine E Dansie1, Stacy Reeves1, Karen Miller1, Stephen P Zano1, Matthew Frank1, Caroline Pate1, Jina Wang1, Suzanne Jackowski1.   

Abstract

CoA (coenzyme A) is an essential cofactor that is involved in many metabolic processes. CoA is derived from pantothenate in five biosynthetic reactions. The CoA biosynthetic pathway is regulated by PanKs (pantothenate kinases) and four active isoforms are expressed in mammals. The critical physiological functions of the PanKs are revealed by systematic deletion of the Pank genes in mice.

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Year:  2014        PMID： 25109998      PMCID： PMC4948118          DOI： 10.1042/BST20140096

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  10 in total

1.  Determination of coenzyme A and acetyl CoA in tissue extracts.

Authors:  J B Allred; D G Guy
Journal:  Anal Biochem       Date:  1969-05       Impact factor: 3.365

2.  Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine.

Authors:  Roberta Leonardi; Charles O Rock; Suzanne Jackowski; Yong-Mei Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-22       Impact factor: 11.205

3.  Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

Authors:  Roberta Leonardi; Yong-Mei Zhang; Mi-Kyung Yun; Ruobing Zhou; Fu-Yue Zeng; Wenwei Lin; Jimmy Cui; Taosheng Chen; Charles O Rock; Stephen W White; Suzanne Jackowski
Journal:  Chem Biol       Date:  2010-08-27

4.  Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state.

Authors:  Roberta Leonardi; Jerold E Rehg; Charles O Rock; Suzanne Jackowski
Journal:  PLoS One       Date:  2010-06-14       Impact factor: 3.240

5.  Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue.

Authors:  Paul E Minkler; Janos Kerner; Stephen T Ingalls; Charles L Hoppel
Journal:  Anal Biochem       Date:  2008-02-29       Impact factor: 3.365

6.  Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats.

Authors:  Katsumi Shibata; Takumi Nakai; Tsutomu Fukuwatari
Journal:  Anal Biochem       Date:  2012-08-23       Impact factor: 3.365

Review 7.  Derivatization of thiol-containing compounds.

Authors:  K Shimada; K Mitamura
Journal:  J Chromatogr B Biomed Appl       Date:  1994-09-23

8.  Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.

Authors:  Matthew Garcia; Roberta Leonardi; Yong-Mei Zhang; Jerold E Rehg; Suzanne Jackowski
Journal:  PLoS One       Date:  2012-07-17       Impact factor: 3.240

9.  Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model.

Authors:  Dario Brunetti; Sabrina Dusi; Carla Giordano; Costanza Lamperti; Michela Morbin; Valeria Fugnanesi; Silvia Marchet; Gigliola Fagiolari; Ody Sibon; Maurizio Moggio; Giulia d'Amati; Valeria Tiranti
Journal:  Brain       Date:  2013-12-06       Impact factor: 13.501

10.  Compartmentalization of mammalian pantothenate kinases.

Authors:  Adolfo Alfonso-Pecchio; Matthew Garcia; Roberta Leonardi; Suzanne Jackowski
Journal:  PLoS One       Date:  2012-11-13       Impact factor: 3.240
  10 in total
  27 in total

1.  Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.

Authors:  Deborah R Corbin; Jerold E Rehg; Danielle L Shepherd; Peter Stoilov; Ryan J Percifield; Linda Horner; Sharon Frase; Yong-Mei Zhang; Charles O Rock; John M Hollander; Suzanne Jackowski; Roberta Leonardi
Journal:  Mol Genet Metab       Date:  2017-02-03       Impact factor: 4.797

2.  Human pantothenate kinase 4 is a pseudo-pantothenate kinase.

Authors:  Jiangwei Yao; Chitra Subramanian; Charles O Rock; Suzanne Jackowski
Journal:  Protein Sci       Date:  2019-04-17       Impact factor: 6.725

3.  Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.

Authors:  Jennifer A Bohn; Jamie L Van Etten; Trista L Schagat; Brittany M Bowman; Richard C McEachin; Peter L Freddolino; Aaron C Goldstrohm
Journal:  Nucleic Acids Res       Date:  2018-01-09       Impact factor: 16.971

4.  A pantothenate kinase-deficient mouse model reveals a gene expression program associated with brain coenzyme a reduction.

Authors:  Chitra Subramanian; Jiangwei Yao; Matthew W Frank; Charles O Rock; Suzanne Jackowski
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2020-01-07       Impact factor: 5.187

5.  Allosteric Regulation of Mammalian Pantothenate Kinase.

Authors:  Chitra Subramanian; Mi-Kyung Yun; Jiangwei Yao; Lalit Kumar Sharma; Richard E Lee; Stephen W White; Suzanne Jackowski; Charles O Rock
Journal:  J Biol Chem       Date:  2016-08-23       Impact factor: 5.157

6.  Nudt8 is a novel CoA diphosphohydrolase that resides in the mitochondria.

Authors:  Evan W Kerr; Stephanie A Shumar; Roberta Leonardi
Journal:  FEBS Lett       Date:  2019-05-02       Impact factor: 4.124

7.  Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.

Authors:  Stephanie A Shumar; Evan W Kerr; Werner J Geldenhuys; Grace E Montgomery; Paolo Fagone; Puchong Thirawatananond; Harry Saavedra; Sandra B Gabelli; Roberta Leonardi
Journal:  J Biol Chem       Date:  2018-01-29       Impact factor: 5.157

8.  Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.

Authors:  Stephen P Zano; Caroline Pate; Matthew Frank; Charles O Rock; Suzanne Jackowski
Journal:  Mol Genet Metab       Date:  2015-10-29       Impact factor: 4.797

9.  Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.

Authors:  Randall L Woltjer; Lindsay C Reese; Brian E Richardson; Huong Tran; Sarah Green; Thao Pham; Megan Chalupsky; Isabella Gabriel; Tyler Light; Lynn Sanford; Suh Young Jeong; Jeffrey Hamada; Leila K Schwanemann; Caleb Rogers; Allison Gregory; Penelope Hogarth; Susan J Hayflick
Journal:  Mol Genet Metab       Date:  2015-10-31       Impact factor: 4.797

Review 10.  Regulation of coenzyme A levels by degradation: the 'Ins and Outs'.

Authors:  Philippe Naquet; Evan W Kerr; Schuyler D Vickers; Roberta Leonardi
Journal:  Prog Lipid Res       Date:  2020-03-29       Impact factor: 16.195
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