Brian P Mulhall1, Stephen Wright1, Debbie Allen2, Katherine Brown3, Bridget Dickson4, Miriam Grotowski5, Eva Jackson6, Kathy Petoumenos1, Phillip Read1, Timothy Read7, Darren Russell8, David J Smith9, David J Templeton1, Christopher K Fairley7, Matthew G Law1. 1. The Kirby Institute for Infection and Immunity in Society, Wallace Wurth Building, University of New South Wales, Sydney, NSW 2052, Australia. 2. Holden Street Sexual Health Clinic, PO Box 361, Gosford, NSW 2250, Australia. 3. University of Sydney, Camperdown, NSW 2006, Australia. 4. Caradata, PO Box 579, Arundel DC, Qld 4214, Australia. 5. Clinic 468, Tamworth Sexual Health, Hunter New England Area Health Service, NSW 2340, Australia. 6. Nepean/Blue Mountains Sexual Health, Nepean Hospital, Kingswood NSW 2747, Australia. 7. Melbourne Sexual Health Centre, Alfred Hospital, Prahran, Vic. 3181, Australia. 8. Cairns Sexual Health Service, PO Box 902, Cairns, Qld 4214, Australia. 9. Lismore Sexual Health Services, 4 Shepherd Lane, Lismore, NSW 2480, Australia.
Abstract
UNLABELLED: Background In HIV-positive people, sexually transmissible infections (STIs) probably increase the infectiousness of HIV. METHODS: In 2010, we established a cohort of individuals (n=554) from clinics in the Australian HIV Observational Database (AHOD). We calculated retrospective rates for four STIs for 2005-10 and prospective incidence rates for 2010-11. RESULTS: At baseline (2010), patient characteristics were similar to the rest of AHOD. Overall incidence was 12.5 per 100 person-years. Chlamydial infections increased from 3.4 per 100 person-years (95% confidence interval (CI): 1.9-5.7) in 2005 to 6.7 per 100 person-years (95% CI: 4.5-9.5) in 2011, peaking in 2010 (8.1 per 100 person-years; 95% CI: 5.6-11.2). Cases were distributed among rectal (61.9%), urethral (34%) and pharyngeal (6.3%) sites. Gonococcal infections increased, peaking in 2010 (4.7 per 100 person-years; 95% CI: 5.6-11.2; Ptrend=0.0099), distributed among rectal (63.9%), urethral (27.9%) and pharyngeal (14.8%) sites. Syphilis showed several peaks, the largest in 2008 (5.3 per 100 person-years; 95% CI: 3.3-8.0); the overall trend was not significant (P=0.113). Genital warts declined from 7.5 per 100 person-years (95% CI: 4.8-11.3) in 2005 to 2.4 per 100 person-years (95% CI: 1.1-4.5) in 2011 (Ptrend=0.0016). CONCLUSIONS: For chlamydial and gonococcal infections, incidence was higher than previous Australian estimates among HIV-infected men who have sex with men, increasing during 2005-2011. Rectal infections outnumbered infections at other sites. Syphilis incidence remained high but did not increase; that of genital warts was lower and decreased.
UNLABELLED: Background In HIV-positivepeople, sexually transmissible infections (STIs) probably increase the infectiousness of HIV. METHODS: In 2010, we established a cohort of individuals (n=554) from clinics in the Australian HIV Observational Database (AHOD). We calculated retrospective rates for four STIs for 2005-10 and prospective incidence rates for 2010-11. RESULTS: At baseline (2010), patient characteristics were similar to the rest of AHOD. Overall incidence was 12.5 per 100 person-years. Chlamydial infections increased from 3.4 per 100 person-years (95% confidence interval (CI): 1.9-5.7) in 2005 to 6.7 per 100 person-years (95% CI: 4.5-9.5) in 2011, peaking in 2010 (8.1 per 100 person-years; 95% CI: 5.6-11.2). Cases were distributed among rectal (61.9%), urethral (34%) and pharyngeal (6.3%) sites. Gonococcal infections increased, peaking in 2010 (4.7 per 100 person-years; 95% CI: 5.6-11.2; Ptrend=0.0099), distributed among rectal (63.9%), urethral (27.9%) and pharyngeal (14.8%) sites. Syphilis showed several peaks, the largest in 2008 (5.3 per 100 person-years; 95% CI: 3.3-8.0); the overall trend was not significant (P=0.113). Genital warts declined from 7.5 per 100 person-years (95% CI: 4.8-11.3) in 2005 to 2.4 per 100 person-years (95% CI: 1.1-4.5) in 2011 (Ptrend=0.0016). CONCLUSIONS: For chlamydial and gonococcal infections, incidence was higher than previous Australian estimates among HIV-infectedmen who have sex with men, increasing during 2005-2011. Rectal infections outnumbered infections at other sites. Syphilis incidence remained high but did not increase; that of genital warts was lower and decreased.
Authors: Helen Ward; Iona Martin; Neil Macdonald; Sarah Alexander; Ian Simms; Kevin Fenton; Patrick French; Gillian Dean; Catherine Ison Journal: Clin Infect Dis Date: 2006-11-27 Impact factor: 9.079
Authors: Kristi E Gamarel; Sharon Nichols; Christopher W Kahler; Andrew O Westfall; Michelle A Lally; Craig M Wilson Journal: Sex Transm Infect Date: 2017-11-27 Impact factor: 3.519
Authors: B P Mulhall; S T Wright; N De La Mata; D Allen; K Brown; B Dickson; M Grotowski; E Jackson; K Petoumenos; R Foster; T Read; D Russell; D J Smith; D J Templeton; C K Fairley; M G Law Journal: HIV Med Date: 2016-03-28 Impact factor: 3.180