Literature DB >> 25109571

In vivo veritas: (+)-Naltrexone's actions define translational importance: A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'.

Linda R Watkins1, Xiaohui Wang2, Sanam Mustafa3, Mark R Hutchinson3.   

Abstract

Entities:  

Keywords:  Toll-like receptor 4; analgesia; drug abuse; naloxone; naltrexone; non-stereoselective

Mesh：

Substances：

Year:  2014        PMID： 25109571     DOI： 10.1016/j.tips.2014.07.002

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


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  8 in total

Review 1.  Opioid-induced central immune signaling: implications for opioid analgesia.

Authors:  Peter M Grace; Steven F Maier; Linda R Watkins
Journal:  Headache       Date:  2015-03-31       Impact factor: 5.887

2.  Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.

Authors:  Brandon R Selfridge; Xiaohui Wang; Yingning Zhang; Hang Yin; Peter M Grace; Linda R Watkins; Arthur E Jacobson; Kenner C Rice
Journal:  J Med Chem       Date:  2015-06-05       Impact factor: 7.446

3.  Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine.

Authors:  Eizoh Gondoh; Yusuke Hamada; Tomohisa Mori; Yusuke Iwazawa; Asami Shinohara; Michiko Narita; Daisuke Sato; Hiroyuki Tezuka; Takayasu Yamauchi; Mayu Tsujimura; Sara Yoshida; Kenichi Tanaka; Kensuke Yamashita; Haruka Akatori; Kimio Higashiyama; Kazuhiko Arakawa; Yukari Suda; Kanako Miyano; Masako Iseki; Eiichi Inada; Naoko Kuzumaki; Minoru Narita
Journal:  Br J Cancer       Date:  2022-08-09       Impact factor: 9.075

4.  Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae.

Authors:  P M Grace; K M Ramos; K M Rodgers; X Wang; M R Hutchinson; M T Lewis; K N Morgan; J L Kroll; F R Taylor; K A Strand; Y Zhang; D Berkelhammer; M G Huey; L I Greene; T A Cochran; H Yin; D S Barth; K W Johnson; K C Rice; S F Maier; L R Watkins
Journal:  Neuroscience       Date:  2014-09-18       Impact factor: 3.590

5.  Role of the δ-Opioid Receptor in 2 Murine Models of Colitis.

Authors:  Tia R Bobo; Leo R Fitzpatrick; Tiffany L Whitcomb; Timothy K Cooper; Sorana Raiciulescu; Jill P Smith
Journal:  Comp Med       Date:  2020-01-22       Impact factor: 0.982

6.  Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4.

Authors:  X Wang; Y Zhang; Y Peng; M R Hutchinson; K C Rice; H Yin; L R Watkins
Journal:  Br J Pharmacol       Date:  2016-02-04       Impact factor: 8.739

7.  Low dose Naltrexone for induction of remission in inflammatory bowel disease patients.

Authors:  Mitchell R K L Lie; Janine van der Giessen; Gwenny M Fuhler; Alison de Lima; Maikel P Peppelenbosch; Cokkie van der Ent; C Janneke van der Woude
Journal:  J Transl Med       Date:  2018-03-09       Impact factor: 5.531

Review 8.  The Role of Opioid Receptors in Immune System Function.

Authors:  Toby K Eisenstein
Journal:  Front Immunol       Date:  2019-12-20       Impact factor: 7.561
  8 in total

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