Literature DB >> 25108565

How chemistry supports cell biology: the chemical toolbox at your service.

Ruud H Wijdeven1, Jacques Neefjes2, Huib Ovaa3.   

Abstract

Chemical biology is a young and rapidly developing scientific field. In this field, chemistry is inspired by biology to create various tools to monitor and modulate biochemical and cell biological processes. Chemical contributions such as small-molecule inhibitors and activity-based probes (ABPs) can provide new and unique insights into previously unexplored cellular processes. This review provides an overview of recent breakthroughs in chemical biology that are likely to have a significant impact on cell biology. We also discuss the application of several chemical tools in cell biology research.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Keywords:  activity-based profiling; chemical biology; chemical genetics

Mesh：

Substances：

Year:  2014        PMID： 25108565     DOI： 10.1016/j.tcb.2014.07.002

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  8 in total

1.  SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

Authors:  Anna M Knapinska; Daniela Dreymuller; Andreas Ludwig; Lyndsay Smith; Vladislav Golubkov; Anjum Sohail; Rafael Fridman; Marc Giulianotti; Travis M LaVoi; Richard A Houghten; Gregg B Fields; Dmitriy Minond
Journal:  J Med Chem       Date:  2015-08-04       Impact factor: 7.446

Review 2.  Recent progress in the imaging detection of enzyme activities in vivo.

Authors:  Chunjie Yang; Qian Wang; Wu Ding
Journal:  RSC Adv       Date:  2019-08-13       Impact factor: 4.036

3.  Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome.

Authors:  Paul J Guyett; Shuangluo Xia; David C Swinney; Michael P Pollastri; Kojo Mensa-Wilmot
Journal:  ACS Infect Dis       Date:  2016-06-16       Impact factor: 5.084

Review 4.  Bacteria-host relationship: ubiquitin ligases as weapons of invasion.

Authors:  Timurs Maculins; Evgenij Fiskin; Sagar Bhogaraju; Ivan Dikic
Journal:  Cell Res       Date:  2016-03-11       Impact factor: 25.617

Review 5.  Recent advances in activity-based probes (ABPs) and affinity-based probes (AfBPs) for profiling of enzymes.

Authors:  Haixiao Fang; Bo Peng; Sing Yee Ong; Qiong Wu; Lin Li; Shao Q Yao
Journal:  Chem Sci       Date:  2021-05-18       Impact factor: 9.825

6.  Engineered kinesin motor proteins amenable to small-molecule inhibition.

Authors:  Martin F Engelke; Michael Winding; Yang Yue; Shankar Shastry; Federico Teloni; Sanjay Reddy; T Lynne Blasius; Pushpanjali Soppina; William O Hancock; Vladimir I Gelfand; Kristen J Verhey
Journal:  Nat Commun       Date:  2016-04-05       Impact factor: 14.919

Review 7.  Chemicals as the Sole Transformers of Cell Fate.

Authors:  Behnam Ebrahimi
Journal:  Int J Stem Cells       Date:  2016-05-30       Impact factor: 2.500

Review 8.  Targeting protein function: the expanding toolkit for conditional disruption.

Authors:  Amy E Campbell; Daimark Bennett
Journal:  Biochem J       Date:  2016-09-01       Impact factor: 3.857
  8 in total

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