Seul Ki Kim1, Jang Mi Lee1, Byung Chul Jee2, Chang Suk Suh3, Seok Hyun Kim4. 1. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Bundang, South Korea. 2. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Bundang, South Korea; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: blasto@snubh.org. 3. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Bundang, South Korea; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea. 4. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.
Abstract
OBJECTIVE: To study variations in semen parameters among cancer patients who visited a sperm banking clinic before undergoing cancer treatment. DESIGN: Retrospective, consecutive study. SETTING: University-based hospital. PATIENT(S): Eighty-six patients, diagnosed with various cancers, undergoing multiple semen collections on 5 consecutive days, for fertility preservation, between 2004 and 2013. INTERVENTION(S): None. MAIN OUTCOME MEASURES: Within- and between-subject coefficients of variation were estimated using a random-effects analysis of variance to assess the consistency of semen parameters (volume, sperm concentration, motility, rapid motility, total motile sperm count, and computer-based sperm parameters), whereas intraclass correlation coefficients (ICCs) were calculated to assess the size of the between-component of variance relative to the total component of variance. RESULT(S): When analyzing semen parameters over a maximum of 5 consecutive days, only the semen volume was significantly reduced in day-1 and -3 samples compared with the first sample. Almost all of the parameters showed high ICC values, suggesting that within-subject fluctuations were small relative to the between-subject variability. The highest ICC values were noted in volume (ICC 0.76; 95% confidence interval [CI] 0.52-0.89), followed by total motile count (ICC 0.71; 95% CI 0.30-0.89); the least consistent measure was wobble (ICC 0.14; 95% CI -0.13, 0.51). CONCLUSION(S): Repeated ejaculates from cancer patients did not show substantial variation in semen quality.
OBJECTIVE: To study variations in semen parameters among cancerpatients who visited a sperm banking clinic before undergoing cancer treatment. DESIGN: Retrospective, consecutive study. SETTING: University-based hospital. PATIENT(S): Eighty-six patients, diagnosed with various cancers, undergoing multiple semen collections on 5 consecutive days, for fertility preservation, between 2004 and 2013. INTERVENTION(S): None. MAIN OUTCOME MEASURES: Within- and between-subject coefficients of variation were estimated using a random-effects analysis of variance to assess the consistency of semen parameters (volume, sperm concentration, motility, rapid motility, total motile sperm count, and computer-based sperm parameters), whereas intraclass correlation coefficients (ICCs) were calculated to assess the size of the between-component of variance relative to the total component of variance. RESULT(S): When analyzing semen parameters over a maximum of 5 consecutive days, only the semen volume was significantly reduced in day-1 and -3 samples compared with the first sample. Almost all of the parameters showed high ICC values, suggesting that within-subject fluctuations were small relative to the between-subject variability. The highest ICC values were noted in volume (ICC 0.76; 95% confidence interval [CI] 0.52-0.89), followed by total motile count (ICC 0.71; 95% CI 0.30-0.89); the least consistent measure was wobble (ICC 0.14; 95% CI -0.13, 0.51). CONCLUSION(S): Repeated ejaculates from cancerpatients did not show substantial variation in semen quality.
Authors: Christopher L R Barratt; Lars Björndahl; Christopher J De Jonge; Dolores J Lamb; Francisco Osorio Martini; Robert McLachlan; Robert D Oates; Sheryl van der Poel; Bianca St John; Mark Sigman; Rebecca Sokol; Herman Tournaye Journal: Hum Reprod Update Date: 2017-11-01 Impact factor: 15.610