Seok Kyo Seo1, Bo Hyon Yun1, Seung Joo Chon1, Yoo Jin Lee1, E-Jung Han1, Joo Hyun Park1, SiHyun Cho2, Young Sik Choi1, Byung Seok Lee3. 1. Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Institute of Women's Life Medical Science, Seoul, Republic of Korea. 2. Institute of Women's Life Medical Science, Seoul, Republic of Korea; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 3. Institute of Women's Life Medical Science, Seoul, Republic of Korea; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: dr222@yuhs.ac.
Abstract
BACKGROUND: Several studies have suggested that increased iron storage may promote the development of atherosclerotic coronary heart disease. In the present study, we aimed to investigate the association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women. METHODS: We examined 280 postmenopausal women who visited the health promotion center of our hospital for a routine health checkup. Metabolic syndrome was diagnosed by using the revised criteria of the National Cholesterol Education Program Adult Treatment Panel III. The presence of coronary atherosclerosis was indicated by 64-row multi-detector computed tomography. RESULTS: The proportion of postmenopausal women with metabolic syndrome and coronary atherosclerosis in the highest ferritin quartile was significantly higher compared with that in the lowest quartile. Serum ferritin levels were independently associated with the presence of metabolic syndrome (adjusted odds ratio for the highest quartile versus the lowest quartile, 3.313; 95% confidence interval, 1.251-8.775) and coronary atherosclerosis (adjusted odds ratio for the highest quartile versus the lowest quartile, 3.047; 95% confidence interval, 1.026-9.051), after adjusting for confounding factors. CONCLUSIONS: Elevated serum ferritin levels may be associated with an increased risk of metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women.
BACKGROUND: Several studies have suggested that increased iron storage may promote the development of atherosclerotic coronary heart disease. In the present study, we aimed to investigate the association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women. METHODS: We examined 280 postmenopausal women who visited the health promotion center of our hospital for a routine health checkup. Metabolic syndrome was diagnosed by using the revised criteria of the National Cholesterol Education Program Adult Treatment Panel III. The presence of coronary atherosclerosis was indicated by 64-row multi-detector computed tomography. RESULTS: The proportion of postmenopausal women with metabolic syndrome and coronary atherosclerosis in the highest ferritin quartile was significantly higher compared with that in the lowest quartile. Serum ferritin levels were independently associated with the presence of metabolic syndrome (adjusted odds ratio for the highest quartile versus the lowest quartile, 3.313; 95% confidence interval, 1.251-8.775) and coronary atherosclerosis (adjusted odds ratio for the highest quartile versus the lowest quartile, 3.047; 95% confidence interval, 1.026-9.051), after adjusting for confounding factors. CONCLUSIONS: Elevated serum ferritin levels may be associated with an increased risk of metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women.
Authors: Min Kyoung Kim; Seung Joo Chon; Yeon Soo Jung; Bo Ok Kim; Eun Bee Noe; Bo Hyon Yun; SiHyun Cho; Young Sik Choi; Byung Seok Lee; Seok Kyo Seo Journal: PLoS One Date: 2016-06-23 Impact factor: 3.240