Haijian Zhou1, Xiaoying Shan2, Xiaofang Sun3, Li Xu4, Yuan Gao4, Machao Li4, Zhujun Shao5. 1. State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China. Electronic address: zhouhaijian@icdc.cn. 2. State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; School of Public Health, Shandong University, Jinan, People's Republic of China; Jinan Municipal Center for Disease Control and Prevention, Jinan, People's Republic of China. 3. State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. 4. State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China. 5. State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China. Electronic address: shaozhujun@icdc.cn.
Abstract
OBJECTIVES: To reveal the population structure of invasive Neisseria meningitidis isolates after the initiation of an A + C vaccination program in China. METHODS: Multilocus sequence typing (MLST) and PorA typing were used to characterize 238 invasive N. meningitidis isolates collected in China between 2005 and 2012. RESULTS: During this period, sequence type (ST)-5, ST-4821 and ST-11 complexes were dominant among serogroups A, C and W, accounting for 100%, 98.5% and 100% of each serogroup, respectively. P1.20,9, P1.7-2,14 and P1.5,2 were the dominant PorA types of serogroups A, C and W, respectively. Serogroup B showed high genetic diversity with two dominant lineages: ST-4821 complex and ST-5662 subgroup. CONCLUSIONS: The population of 238 invasive N. meningitidis isolates was primarily composed of a select group of recognized hypervirulent lineages. Among these clonal complexes, ST-7 serogroup A and ST-11 serogroup W are distributed globally, and other three clones exist only in China.
OBJECTIVES: To reveal the population structure of invasive Neisseria meningitidis isolates after the initiation of an A + C vaccination program in China. METHODS: Multilocus sequence typing (MLST) and PorA typing were used to characterize 238 invasive N. meningitidis isolates collected in China between 2005 and 2012. RESULTS: During this period, sequence type (ST)-5, ST-4821 and ST-11 complexes were dominant among serogroups A, C and W, accounting for 100%, 98.5% and 100% of each serogroup, respectively. P1.20,9, P1.7-2,14 and P1.5,2 were the dominant PorA types of serogroups A, C and W, respectively. Serogroup B showed high genetic diversity with two dominant lineages: ST-4821 complex and ST-5662 subgroup. CONCLUSIONS: The population of 238 invasive N. meningitidis isolates was primarily composed of a select group of recognized hypervirulent lineages. Among these clonal complexes, ST-7 serogroup A and ST-11 serogroup W are distributed globally, and other three clones exist only in China.
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