PURPOSE: To elucidate the problems in infertility treatment for women after conservative therapy for endometrial cancer (EC) or atypical complex endometrial hyperplasia (ACEH). METHODS: The clinical outcomes of 21 patients who underwent assisted reproductive technology after conservative therapy (group A) and 42 control women (group B) were retrospectively analyzed. RESULTS: There was no significant difference in the number of retrieved oocytes, fertilization rate or the number of transferred embryos between the two groups. Women in group A had a significantly thinner endometrium and a reduced implantation rate compared to those for women in group B. There was no significant difference in the cumulative clinical pregnancy and delivery rates between group A and B. The patients in group A required significantly more embryos for achieving a live-birth. CONCLUSIONS: Our results indicate that a thin endometrium after repeated curettage may have a negative effect on endometrial receptivity of patients after conservative treatment for EC/ACEH. Clinicians should reconsider their present protocols and make efforts to minimize the damage to normal endometrium.
PURPOSE: To elucidate the problems in infertility treatment for women after conservative therapy for endometrial cancer (EC) or atypical complex endometrial hyperplasia (ACEH). METHODS: The clinical outcomes of 21 patients who underwent assisted reproductive technology after conservative therapy (group A) and 42 control women (group B) were retrospectively analyzed. RESULTS: There was no significant difference in the number of retrieved oocytes, fertilization rate or the number of transferred embryos between the two groups. Women in group A had a significantly thinner endometrium and a reduced implantation rate compared to those for women in group B. There was no significant difference in the cumulative clinical pregnancy and delivery rates between group A and B. The patients in group A required significantly more embryos for achieving a live-birth. CONCLUSIONS: Our results indicate that a thin endometrium after repeated curettage may have a negative effect on endometrial receptivity of patients after conservative treatment for EC/ACEH. Clinicians should reconsider their present protocols and make efforts to minimize the damage to normal endometrium.
Authors: J C Dumoulin; E Coonen; M Bras; L C van Wissen; R Ignoul-Vanvuchelen; J M Bergers-Jansen; J G Derhaag; J P Geraedts; J L Evers Journal: Hum Reprod Date: 2000-02 Impact factor: 6.918
Authors: Ioannis D Gallos; Jason Yap; Madhurima Rajkhowa; David M Luesley; Arri Coomarasamy; Janesh K Gupta Journal: Am J Obstet Gynecol Date: 2012-08-10 Impact factor: 8.661
Authors: D J McLernon; K Harrild; C Bergh; M J Davies; D de Neubourg; J C M Dumoulin; J Gerris; J A M Kremer; H Martikainen; B W Mol; R J Norman; A Thurin-Kjellberg; A Tiitinen; A P A van Montfoort; A M van Peperstraten; E Van Royen; S Bhattacharya Journal: BMJ Date: 2010-12-21
Authors: Barbara Buonomo; Roberto Orecchia; Federica Tomao; Lino Del Pup; Alex Garcia-Faura; Fedro A Peccatori Journal: Ecancermedicalscience Date: 2020-05-06