Literature DB >> 25105576

Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis.

Nagarajan Kannan1, Connie J Eaves2.   

Abstract

Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25105576     DOI： 10.1016/j.stem.2014.07.010

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  4 in total

1.  SND1 acts as a novel gene transcription activator recognizing the conserved Motif domains of Smad promoters, inducing TGFβ1 response and breast cancer metastasis.

Authors:  L Yu; Y Di; L Xin; Y Ren; X Liu; X Sun; W Zhang; Z Yao; J Yang
Journal:  Oncogene       Date:  2017-03-06       Impact factor: 9.867

2.  SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma.

Authors:  Xiaoteng Cui; Chunyan Zhao; Xuyang Yao; Baoxin Qian; Chao Su; Yuanyuan Ren; Zhi Yao; Xingjie Gao; Jie Yang
Journal:  RNA Biol       Date:  2018-10-25       Impact factor: 4.652

3.  Tudor-SN Regulates Milk Synthesis and Proliferation of Bovine Mammary Epithelial Cells.

Authors:  Jinxia Ao; Chengjie Wei; Yu Si; Chaochao Luo; Wei Lv; Ye Lin; Yingjun Cui; Xuejun Gao
Journal:  Int J Mol Sci       Date:  2015-12-16       Impact factor: 5.923

4.  Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.

Authors:  Shiwei Liang; Chuxu Zhu; Caixia Suo; Haoran Wei; Yingxuan Yu; Xuemei Gu; Liang Chen; Mengqiu Yuan; Shengqi Shen; Shiting Li; Linchong Sun; Ping Gao
Journal:  Front Oncol       Date:  2022-03-31       Impact factor: 6.244
  4 in total

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