Literature DB >> 25105574

The tailless root of glioma: cancer stem cells.

Qi Xie1, William A Flavahan1, Shideng Bao1, Jeremy Rich2.   

Abstract

In this issue of Cell Stem Cell, Zhu et al. (2014) demonstrate that a genetically engineered glioma model displays a functional cellular hierarchy defined by expression of the nuclear orphan receptor Tlx. Targeting cancer stem cells through genetic deletion of TLX promotes cancer stem cell death and differentiation and extends survival.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25105574      PMCID： PMC4239656          DOI： 10.1016/j.stem.2014.07.004

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

1.  Expression and function of orphan nuclear receptor TLX in adult neural stem cells.

Authors:  Yanhong Shi; D Chichung Lie; Philippe Taupin; Kinichi Nakashima; Jasodhara Ray; Ruth T Yu; Fred H Gage; Ronald M Evans
Journal:  Nature       Date:  2004-01-01       Impact factor: 49.962

2.  The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone.

Authors:  Hai-Kun Liu; Thorsten Belz; Dagmar Bock; Andrea Takacs; Hui Wu; Peter Lichter; Minqiang Chai; Günther Schütz
Journal:  Genes Dev       Date:  2008-09-15       Impact factor: 11.361

3.  The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation.

Authors:  Hai-Kun Liu; Ying Wang; Thorsten Belz; Dagmar Bock; Andrea Takacs; Bernhard Radlwimmer; Sebastian Barbus; Guido Reifenberger; Peter Lichter; Günther Schütz
Journal:  Genes Dev       Date:  2010-04-01       Impact factor: 11.361

4.  The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.

Authors:  Yuhua Zou; Wenze Niu; Song Qin; Michael Downes; Dennis K Burns; Chun-Li Zhang
Journal:  Mol Cell Biol       Date:  2012-10-01       Impact factor: 4.272

5.  The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells.

Authors:  Hyo-Jung Park; Jun-Kyum Kim; Hye-Min Jeon; Se-Yeong Oh; Sung-Hak Kim; Do-Hyun Nam; Hyunggee Kim
Journal:  Mol Cells       Date:  2010-08-31       Impact factor: 5.034

6.  Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Authors:  Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark W Dewhirst; Darell D Bigner; Jeremy N Rich
Journal:  Nature       Date:  2006-10-18       Impact factor: 49.962

7.  Gene expression profiling and genetic markers in glioblastoma survival.

Authors:  Jeremy N Rich; Christopher Hans; Beatrix Jones; Edwin S Iversen; Roger E McLendon; B K Ahmed Rasheed; Adrian Dobra; Holly K Dressman; Darell D Bigner; Joseph R Nevins; Mike West
Journal:  Cancer Res       Date:  2005-05-15       Impact factor: 12.701

8.  Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation.

Authors:  Guoqiang Sun; Ruth T Yu; Ronald M Evans; Yanhong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-14       Impact factor: 11.205

9.  Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival.

Authors:  Zhe Zhu; Muhammad Amir Khan; Markus Weiler; Jonas Blaes; Leonie Jestaedt; Madeleine Geibert; Peng Zou; Jan Gronych; Olga Bernhardt; Andrey Korshunov; Verena Bugner; Peter Lichter; Bernhard Radlwimmer; Sabine Heiland; Martin Bendszus; Wolfgang Wick; Hai-Kun Liu
Journal:  Cell Stem Cell       Date:  2014-05-15       Impact factor: 24.633

10.  The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.

Authors:  Cindy Benod; Rosa Villagomez; Carly S Filgueira; Peter K Hwang; Paul G Leonard; Guillaume Poncet-Montange; Senapathy Rajagopalan; Robert J Fletterick; Jan-Åke Gustafsson; Paul Webb
Journal:  PLoS One       Date:  2014-06-17       Impact factor: 3.240
  10 in total
  5 in total

1.  Blocking the CD47-SIRPα axis by delivery of anti-CD47 antibody induces antitumor effects in glioma and glioma stem cells.

Authors:  Feng Li; Bingke Lv; Yang Liu; Tian Hua; Jianbang Han; Chengmei Sun; Limin Xu; Zhongfei Zhang; Zhiming Feng; Yingqian Cai; Yuxi Zou; Yiquan Ke; Xiaodan Jiang
Journal:  Oncoimmunology       Date:  2017-11-06       Impact factor: 8.110

2.  Structural basis for corepressor assembly by the orphan nuclear receptor TLX.

Authors:  Xiaoyong Zhi; X Edward Zhou; Yuanzheng He; Kelvin Searose-Xu; Chun-Li Zhang; Chih-Cheng Tsai; Karsten Melcher; H Eric Xu
Journal:  Genes Dev       Date:  2015-02-15       Impact factor: 11.361

3.  MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species.

Authors:  Wei Yang; Yueming Shen; Jing Wei; Fenju Liu
Journal:  Oncotarget       Date:  2015-09-08

4.  HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions.

Authors:  Pan Wang; Sheng Gong; Bin Liao; Jinyu Pan; Junwei Wang; Dewei Zou; Lu Zhao; Shuanglong Xiong; Yangmin Deng; Qian Yan; Nan Wu
Journal:  J Cancer       Date:  2022-01-01       Impact factor: 4.207

5.  Comparative transcriptomics reveals similarities and differences between astrocytoma grades.

Authors:  Michael Seifert; Martin Garbe; Betty Friedrich; Michel Mittelbronn; Barbara Klink
Journal:  BMC Cancer       Date:  2015-12-16       Impact factor: 4.430
  5 in total

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