Seung Hak Lee1, Byung-Mo Oh2, Gangpyo Lee1, Hongyoon Choi3, Gi Jeong Cheon3, Shi-Uk Lee4. 1. Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, South Korea shiuk.lee@gmail.com. 2. Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, South Korea. 3. Department of Nuclear Medicine, Seoul National University Hospital, Seoul, South Korea; and. 4. Department of Rehabilitation Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea shiuk.lee@gmail.com.
Abstract
UNLABELLED: The purpose of this study was to confirm glucose hypermetabolism in denervated muscle and investigate the feasibility of (18)F-FDG PET scanning for the detection of muscle denervation. METHOD: A sciatic neuropathy model in rats was created by nerve resection of the left sciatic nerve and sham operation on the other side. Eight days after denervation, small-animal PET/CT scans of the hindlimbs were acquired. Muscle denervation was confirmed by electrophysiologic and histologic study. RESULTS: All rats showed increased (18)F-FDG uptake in the muscles of the left (denervated) lower legs. The calculated maximum lesion-to-normal counts ratio of the left lower leg anterolateral (left, 11.02 ± 2.08; right, 1.81 ± 0.40, n = 6, P < 0.01) and posterior (left, 9.81 ± 4.58; right, 1.87 ± 0.44, n = 6, P < 0.01) compartment were significantly increased. The electrophysiologic and histologic study verified muscle denervation. CONCLUSION: Glucose hypermetabolism in muscle denervation is an obvious phenomenon. (18)F-FDG PET scanning can be used to visualize muscle denervation.
UNLABELLED: The purpose of this study was to confirm glucose hypermetabolism in denervated muscle and investigate the feasibility of (18)F-FDG PET scanning for the detection of muscle denervation. METHOD:A sciatic neuropathy model in rats was created by nerve resection of the left sciatic nerve and sham operation on the other side. Eight days after denervation, small-animal PET/CT scans of the hindlimbs were acquired. Muscle denervation was confirmed by electrophysiologic and histologic study. RESULTS: All rats showed increased (18)F-FDG uptake in the muscles of the left (denervated) lower legs. The calculated maximum lesion-to-normal counts ratio of the left lower leg anterolateral (left, 11.02 ± 2.08; right, 1.81 ± 0.40, n = 6, P < 0.01) and posterior (left, 9.81 ± 4.58; right, 1.87 ± 0.44, n = 6, P < 0.01) compartment were significantly increased. The electrophysiologic and histologic study verified muscle denervation. CONCLUSION:Glucose hypermetabolism in muscle denervation is an obvious phenomenon. (18)F-FDG PET scanning can be used to visualize muscle denervation.
Authors: Timothy R DeGrado; Mukesh K Pandey; Anthony P Belanger; Falguni Basuli; Aditya Bansal; Shuyan Wang Journal: Am J Physiol Endocrinol Metab Date: 2018-12-04 Impact factor: 4.310
Authors: Ji Soo Choi; Han Gil Seo; Byung-Mo Oh; Hongyoon Choi; Gi Jeong Cheon; Shi-Uk Lee; Seung Hak Lee Journal: Ann Clin Transl Neurol Date: 2019-10-06 Impact factor: 4.511