Óscar Fabregat-Andrés1, Jordi Estornell-Erill2, Francisco Ridocci-Soriano3, Pilar García-González4, Bruno Bochard-Villanueva4, Andrés Cubillos-Arango4, Rafael de la Espriella-Juan4, Lorenzo Fácila4, Salvador Morell4, Julio Cortijo5. 1. Cardiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Spain Research Foundation, Hospital General Universitario, Valencia, Spain osfabregat@gmail.com. 2. Cardiac Imaging Unit, ERESA, Valencia, Spain. 3. Cardiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Spain Department of Medicine, Universitat de Valencia, Valencia, Spain. 4. Cardiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Spain. 5. Research Foundation, Hospital General Universitario, Valencia, Spain Department of Pharmacology, Universitat de Valencia, Valencia, Spain.
Abstract
AIMS: Pulmonary arterial hypertension is known to be related to worse prognosis in patients with heart failure (HF). Quantification of pulmonary vascular resistance (PVR) still requires invasive right heart catheterization. Recent studies have shown an accurate method for non-invasive estimation of PVR by cardiac magnetic resonance (CMR). Our aim was to evaluate the prognostic value of PVR calculated by CMR in patients with congestive HF. METHODS AND RESULTS: We calculated PVR by CMR in 132 patients [age 65.6 ± 13.1 years, left ventricular ejection fraction (LVEF) 35.1 ± 16.4%, ischaemic aetiology 40%] recently admitted for decompensated HF and derived to our cardiac imaging unit for diagnosis. Patients with cardiac events (readmission for HF or all-cause death) had higher values of PVR [6.77 ± 1.9 vs. 4.1 ± 1.6 Wood units (Wu), P < 0.001] during follow-up [mean 10.3 (1-31) months]. In multivariable Cox regression analysis, only a PVR ≥5.2 Wu [hazard ratio (HR) 4.27; 95% confidence interval (CI) 1.75-10.42; P < 0.001) and the presence of late gadolinium enhancement (LGE) on CMR (HR 2.24; 95% CI 1.03-4.86; P = 0.04) were independent predictors for adverse events at follow-up. CONCLUSION: Non-invasive estimation of PVR by CMR might be useful for risk stratification of patients with chronic HF, irrespective of aetiology or LVEF. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: Pulmonary arterial hypertension is known to be related to worse prognosis in patients with heart failure (HF). Quantification of pulmonary vascular resistance (PVR) still requires invasive right heart catheterization. Recent studies have shown an accurate method for non-invasive estimation of PVR by cardiac magnetic resonance (CMR). Our aim was to evaluate the prognostic value of PVR calculated by CMR in patients with congestive HF. METHODS AND RESULTS: We calculated PVR by CMR in 132 patients [age 65.6 ± 13.1 years, left ventricular ejection fraction (LVEF) 35.1 ± 16.4%, ischaemic aetiology 40%] recently admitted for decompensated HF and derived to our cardiac imaging unit for diagnosis. Patients with cardiac events (readmission for HF or all-cause death) had higher values of PVR [6.77 ± 1.9 vs. 4.1 ± 1.6 Wood units (Wu), P < 0.001] during follow-up [mean 10.3 (1-31) months]. In multivariable Cox regression analysis, only a PVR ≥5.2 Wu [hazard ratio (HR) 4.27; 95% confidence interval (CI) 1.75-10.42; P < 0.001) and the presence of late gadolinium enhancement (LGE) on CMR (HR 2.24; 95% CI 1.03-4.86; P = 0.04) were independent predictors for adverse events at follow-up. CONCLUSION: Non-invasive estimation of PVR by CMR might be useful for risk stratification of patients with chronic HF, irrespective of aetiology or LVEF. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Blanca Trejo-Velasco; Óscar Fabregat-Andrés; Pilar M García-González; Diana C Perdomo-Londoño; Andrés M Cubillos-Arango; Mónica I Ferrando-Beltrán; Joaquina Belchi-Navarro; José L Pérez-Boscá; Rafael Payá-Serrano; Francisco Ridocci-Soriano Journal: J Cardiovasc Magn Reson Date: 2020-04-30 Impact factor: 5.364
Authors: Óscar Fabregat-Andrés; Jordi Estornell-Erill; Francisco Ridocci-Soriano; José Leandro Pérez-Boscá; Pilar García-González; Rafael Payá-Serrano; Salvador Morell; Julio Cortijo Journal: Arq Bras Cardiol Date: 2016-02-02 Impact factor: 2.000
Authors: Rasmus Rivinius; Matthias Helmschrott; Arjang Ruhparwar; Bastian Schmack; Fabrice F Darche; Dierk Thomas; Tom Bruckner; Andreas O Doesch; Hugo A Katus; Philipp Ehlermann Journal: ESC Heart Fail Date: 2020-02