Literature DB >> 25104733

Cancer signaling: when phosphorylation meets methylation.

Haoqiang Ying1, Ronald A DePinho2.   

Abstract

The propagation of kinase-mediated phosphorylation signals is central to the oncogenic activity of the RAS-MAPK pathway in human cancers. A recent study shows that protein lysine methylation controls the phosphorylation status of a key component of the RAS-MAPK pathway to enable oncogenic KRAS in cancer progression.

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Year:  2014        PMID： 25104733      PMCID： PMC4220151          DOI： 10.1038/cr.2014.103

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.

Authors:  Jaroslaw Daniluk; Yan Liu; Defeng Deng; Jun Chu; Haojie Huang; Sebastian Gaiser; Zobeida Cruz-Monserrate; Huamin Wang; Baoan Ji; Craig D Logsdon
Journal:  J Clin Invest       Date:  2012-03-12       Impact factor: 14.808

2.  Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.

Authors:  Sohini Mukherjee; Gladys Keitany; Yan Li; Yong Wang; Haydn L Ball; Elizabeth J Goldsmith; Kim Orth
Journal:  Science       Date:  2006-05-26       Impact factor: 47.728

Review 3.  Is there a code embedded in proteins that is based on post-translational modifications?

Authors:  Robert J Sims; Danny Reinberg
Journal:  Nat Rev Mol Cell Biol       Date:  2008-09-11       Impact factor: 94.444

Review 4.  Regulating the regulator: post-translational modification of RAS.

Authors:  Ian M Ahearn; Kevin Haigis; Dafna Bar-Sagi; Mark R Philips
Journal:  Nat Rev Mol Cell Biol       Date:  2011-12-22       Impact factor: 94.444

5.  High-resolution genomic profiles of human lung cancer.

Authors:  Giovanni Tonon; Kwok-Kin Wong; Gautam Maulik; Cameron Brennan; Bin Feng; Yunyu Zhang; Deepak B Khatry; Alexei Protopopov; Mingjian James You; Andrew J Aguirre; Eric S Martin; Zhaohui Yang; Hongbin Ji; Lynda Chin; Ronald A Depinho
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-27       Impact factor: 11.205

Review 6.  RAS oncogenes: weaving a tumorigenic web.

Authors:  Yuliya Pylayeva-Gupta; Elda Grabocka; Dafna Bar-Sagi
Journal:  Nat Rev Cancer       Date:  2011-10-13       Impact factor: 60.716

Review 7.  Dragging ras back in the ring.

Authors:  Andrew G Stephen; Dominic Esposito; Rachel K Bagni; Frank McCormick
Journal:  Cancer Cell       Date:  2014-03-17       Impact factor: 31.743

8.  Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.

Authors:  Chi Han Li; Ka-Fai To; Joanna Hung-Man Tong; Zhangang Xiao; Tian Xia; Paul B S Lai; Sheung Ching Chow; Yin-Xin Zhu; Stephen L Chan; Victor E Marquez; Yangchao Chen
Journal:  Gastroenterology       Date:  2013-02-07       Impact factor: 22.682

9.  Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.

Authors:  Rohit Mittal; Sew-Yeu Peak-Chew; Harvey T McMahon
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-20       Impact factor: 11.205

10.  SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.

Authors:  Pawel K Mazur; Nicolas Reynoird; Purvesh Khatri; Pascal W T C Jansen; Alex W Wilkinson; Shichong Liu; Olena Barbash; Glenn S Van Aller; Michael Huddleston; Dashyant Dhanak; Peter J Tummino; Ryan G Kruger; Benjamin A Garcia; Atul J Butte; Michiel Vermeulen; Julien Sage; Or Gozani
Journal:  Nature       Date:  2014-05-21       Impact factor: 49.962
  10 in total
  2 in total

1.  A dual biomarker detection platform for quantitating circulating tumor DNA (ctDNA).

Authors:  Chunyan Cai; Zhenzhong Guo; Yiping Cao; Weiying Zhang; Yong Chen
Journal:  Nanotheranostics       Date:  2018-01-01

2.  Prognostic Value of Eight-Gene Signature in Head and Neck Squamous Carcinoma.

Authors:  Baoling Liu; Quanping Su; Jianhua Ma; Cheng Chen; Lijuan Wang; Fengyuan Che; Xueyuan Heng
Journal:  Front Oncol       Date:  2021-06-18       Impact factor: 6.244
  2 in total

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