| Literature DB >> 25104383 |
Siyu Zhang1, Min Xu1, Tsukasa Kamigaki1, Johnny Phong Hoang Do1, Wei-Cheng Chang1, Sean Jenvay1, Kazunari Miyamichi2, Liqun Luo2, Yang Dan3.
Abstract
Top-down modulation of sensory processing allows the animal to select inputs most relevant to current tasks. We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid-ergic (GABAergic) circuits. Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation). Whereas somatostatin-positive GABAergic interneurons contributed preferentially to surround suppression, vasoactive intestinal peptide-positive interneurons were crucial for center facilitation. Long-range corticocortical projections thus act through local microcircuits to exert spatially specific top-down modulation of sensory processing.Entities:
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Year: 2014 PMID： 25104383 PMCID： PMC5776147 DOI： 10.1126/science.1254126
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728