Zhaleh Mohsenifar1, Mohammad Javad Feridoni2, Mohammad Bayat3, Reza Masteri Farahani2, Shiva Bayat4, Amir Khoshvaghti5. 1. Pathology Department, Ayatallah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran. 2. Anatomy and Biology Department, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran. 3. Anatomy and Biology Department, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran. Electronic address: bayat_m@yahoo.com. 4. Shiraz University of Medical Sciences, Shiraz, Iran. 5. AJA University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: Tendon healing is impaired in patient with diabetes mellitus. The effects of streptozotocin-induced type 1 diabetes (STZ-D) on the healing of the transected Achilles tendon in rats was studied. METHODS: In the experimental group, type one diabetes was induced via administration of STZ. The right Achilles tendon of all the rats was transected 30 days after the STZ administration. The Achilles tendons were examined for biomechanical and histological examinations. RESULTS: The statistical analysis showed that Young's modulus of elasticity and stress tensile load of the control group were significantly higher than those of the experimental group, and inflammation in the experimental group was significantly higher than that in the control group. At the same time, fibrosis in the experimental group was significantly lower than that of the control group. CONCLUSION: Induction of type 1 diabetes by STZ significantly delayed the healing of the transected Achilles tendon in rats.
BACKGROUND: Tendon healing is impaired in patient with diabetes mellitus. The effects of streptozotocin-induced type 1 diabetes (STZ-D) on the healing of the transected Achilles tendon in rats was studied. METHODS: In the experimental group, type one diabetes was induced via administration of STZ. The right Achilles tendon of all the rats was transected 30 days after the STZ administration. The Achilles tendons were examined for biomechanical and histological examinations. RESULTS: The statistical analysis showed that Young's modulus of elasticity and stress tensile load of the control group were significantly higher than those of the experimental group, and inflammation in the experimental group was significantly higher than that in the control group. At the same time, fibrosis in the experimental group was significantly lower than that of the control group. CONCLUSION: Induction of type 1 diabetes by STZ significantly delayed the healing of the transected Achilles tendon in rats.
Authors: Anderson Rodrigues de Oliveira; Flávio Santos da Silva; Raul Hernandes Bortolin; Dáfiny Emanuele da Silva Marques; Gracielle Vieira Ramos; Rita C Marqueti; Naisandra Bezerra da Silva; Karina Carla de Paula Medeiros; Márcio Assolin Corrêa; João Paulo Matos Santos Lima; Adriana Augusto de Rezende; Paul W Ackermann; Bento J Abreu; Wouber Hérickson de Brito Vieira Journal: PLoS One Date: 2019-02-04 Impact factor: 3.240