Riley B Hall1, Sonia N Yeung2, Paul R Yenson3, Gregory Moloney4. 1. Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver General Hospital, Vancouver, B.C.. Electronic address: hall.riley@usask.ca. 2. Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver General Hospital, Vancouver, B.C. 3. Division of Hematology, Department of Medicine, Vancouver General Hospital, Vancouver, B.C. 4. Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver General Hospital, Vancouver, B.C.; Discipline of Ophthalmology, University of Sydney, Sydney Eye Hospital Campus, Macquarie Street, Sydney, New South Wales, Australia.
Abstract
OBJECTIVE: To describe a series of 4 cases of immunotactoid keratopathy (ITK) secondary to monoclonal gammopathy. DESIGN: Multicentre retrospective case series of 4 patients. PARTICIPANTS: Eight eyes of 4 patients presenting to a cornea service with ITK. METHODS: Retrospective case series of 4 patients referred between 2011 and 2013 for bilateral corneal opacities. Work-up including serum protein electrophoresis was performed, and slit-lamp photographs were obtained. RESULTS: After investigation, diagnoses of ITK secondary to monoclonal gammopathy of unknown significance were established in 3 cases. In 1 patient, the diagnosis of monoclonal gammopathy of unknown significance was established prereferral. CONCLUSIONS: ITK secondary to plasma cell disorders can clinically resemble a broad category of disease processes and must be considered when evaluating patients with bilateral peripheral stromal opacities. Our series validates previously proposed classification schemes for these opacities.
OBJECTIVE: To describe a series of 4 cases of immunotactoid keratopathy (ITK) secondary to monoclonal gammopathy. DESIGN: Multicentre retrospective case series of 4 patients. PARTICIPANTS: Eight eyes of 4 patients presenting to a cornea service with ITK. METHODS: Retrospective case series of 4 patients referred between 2011 and 2013 for bilateral corneal opacities. Work-up including serum protein electrophoresis was performed, and slit-lamp photographs were obtained. RESULTS: After investigation, diagnoses of ITK secondary to monoclonal gammopathy of unknown significance were established in 3 cases. In 1 patient, the diagnosis of monoclonal gammopathy of unknown significance was established prereferral. CONCLUSIONS: ITK secondary to plasma cell disorders can clinically resemble a broad category of disease processes and must be considered when evaluating patients with bilateral peripheral stromal opacities. Our series validates previously proposed classification schemes for these opacities.
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