Maoyun Wang1,2,3, Yuchuan Huang2,3,4, Zong'an Liang1,2,3, Dan Liu1,2,3, Yanrong Lu1,2,3, Ya Dai2,3,4, Guanglin Feng2,3,4, Changguo Wang2,3,4. 1. Department of Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China. 2. Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China. 3. Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China. 4. Harmful Components and Tar Reduction in Cigarette, Sichuan Key Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.
Abstract
BACKGROUND AND AIMS: We previously showed that microRNAs (miRNAs) in plasma are potential biomarkers for cigarette smoking-related lung fibrosis. Here, we want to find out promising miRNAs for early detection of chronic obstructive pulmonary disease (COPD). METHODS AND RESULTS: Plasma miRNAs profiling was performed in COPD patients, asthma patients, and matched healthy controls. There was a >2-fold changes for all signature miRNAs between the COPD and control samples, with P values of < 0.05. Pathway analysis, taking into account enriched target mRNAs for these signature miRNAs, was also carried out. We found seven miRNAs were special expression in the COPD patients. Furthermore, changes of miR-145-5p, miR-338-3p and miR-3620-3p were consistent with the classification of new ABCD classification of COPD. Targeted gene promising proved those miRNAs acted in inflammatory mediators, regulation of proliferation and differentiation, oxidative stress and so on. CONCLUSIONS: These results suggested that plasma miRNAs could be potential specific biomarker for early detection COPD.
BACKGROUND AND AIMS: We previously showed that microRNAs (miRNAs) in plasma are potential biomarkers for cigarette smoking-related lung fibrosis. Here, we want to find out promising miRNAs for early detection of chronic obstructive pulmonary disease (COPD). METHODS AND RESULTS: Plasma miRNAs profiling was performed in COPDpatients, asthmapatients, and matched healthy controls. There was a >2-fold changes for all signature miRNAs between the COPD and control samples, with P values of < 0.05. Pathway analysis, taking into account enriched target mRNAs for these signature miRNAs, was also carried out. We found seven miRNAs were special expression in the COPDpatients. Furthermore, changes of miR-145-5p, miR-338-3p and miR-3620-3p were consistent with the classification of new ABCD classification of COPD. Targeted gene promising proved those miRNAs acted in inflammatory mediators, regulation of proliferation and differentiation, oxidative stress and so on. CONCLUSIONS: These results suggested that plasma miRNAs could be potential specific biomarker for early detection COPD.
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