Shanchun Zhang1, Zheyuan Ding2, Hui Liu2, Zexin Chen2, Jinhua Wu3, Youding Zhang4, Yunxian Yu1. 1. Associate Professor, Department of Epidemiology & Health Statistics, School of Public Health, School of Medicine, Zhejiang University; Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. 2. Medical Student, Department of Epidemiology & Health Statistics, School of Public Health, School of Medicine, Zhejiang University; Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. 3. Associate Chief Physician, Zhoushan Maternal and Child Health Hospital, Zhoushan, Zhejiang, China. 4. Chief Physician, Zhoushan Maternal and Child Health Hospital, Zhoushan, Zhejiang, China.
Abstract
BACKGROUND: Hypertensive disorders of pregnant women are one of the important causes of maternal and perinatal morbidity and mortality. Evidence showed mental stress might be a risk factor of gestational hypertensive disorders. OBJECTIVE: The objective of this study was to evaluate the relationships between mental stress and gestational hypertension/preeclampsia in pregnant women. METHODS: Relevant studies were identified by PubMed, Cochrane, Chinese medical datasets (Wanfang, CNKI, and VIP Database). Only case-control or cohort studies evaluating an association of preeclampsia or gestational hypertension with mental stress were included in the present meta-analysis. Essential information was extracted from the qualified studies. Odds ratio (OR) was used as a pooled effect size. Potential heterogeneity and publication bias were detected as well. RESULTS: Thirteen studies were included in the final analyses, which totally recruited 668,005 pregnant women. The results indicated that mental stress was associated with an increased risk of gestational hypertension (OR, 1.26; 95% confidence interval [CI], 1.00-1.59; P = 0.047) and preeclampsia (OR, 1.49; 95%CI, 1.27-1.74; P < 0.001). Meanwhile, work stress (OR, 1.50; 95% CI, 1.15-1.97; P = 0.003) and anxiety or depression (OR, 1.88; 95%CI, 1.08-3.25; P = 0.02)were positively associated with risk of preeclampsia. CONCLUSIONS: Mental stress during life or pregnancy may be a risk factor for gestational hypertension and preeclampsia among pregnant women.
BACKGROUND:Hypertensive disorders of pregnant women are one of the important causes of maternal and perinatal morbidity and mortality. Evidence showed mental stress might be a risk factor of gestational hypertensive disorders. OBJECTIVE: The objective of this study was to evaluate the relationships between mental stress and gestational hypertension/preeclampsia in pregnant women. METHODS: Relevant studies were identified by PubMed, Cochrane, Chinese medical datasets (Wanfang, CNKI, and VIP Database). Only case-control or cohort studies evaluating an association of preeclampsia or gestational hypertension with mental stress were included in the present meta-analysis. Essential information was extracted from the qualified studies. Odds ratio (OR) was used as a pooled effect size. Potential heterogeneity and publication bias were detected as well. RESULTS: Thirteen studies were included in the final analyses, which totally recruited 668,005 pregnant women. The results indicated that mental stress was associated with an increased risk of gestational hypertension (OR, 1.26; 95% confidence interval [CI], 1.00-1.59; P = 0.047) and preeclampsia (OR, 1.49; 95%CI, 1.27-1.74; P < 0.001). Meanwhile, work stress (OR, 1.50; 95% CI, 1.15-1.97; P = 0.003) and anxiety or depression (OR, 1.88; 95%CI, 1.08-3.25; P = 0.02)were positively associated with risk of preeclampsia. CONCLUSIONS: Mental stress during life or pregnancy may be a risk factor for gestational hypertension and preeclampsia among pregnant women.
Authors: Alexa A Freedman; Alison L Cammack; Jeff R Temple; Robert M Silver; Donald J Dudley; Barbara J Stoll; Michael W Varner; George R Saade; Deborah Conway; Robert L Goldenberg; Carol J Hogue Journal: Ann Epidemiol Date: 2017-07-13 Impact factor: 3.797
Authors: Martha M Werler; Samantha E Parker; Klaus Hedman; Mika Gissler; Annukka Ritvanen; Heljä-Marja Surcel Journal: Am J Epidemiol Date: 2016-11-17 Impact factor: 4.897