Literature DB >> 25100820

Molecular typing of Treponema pallidum in the Czech Republic during 2011 to 2013: increased prevalence of identified genotypes and of isolates with macrolide resistance.

Linda Grillová1, Helena Pĕtrošová1, Lenka Mikalová1, Radim Strnadel2, Eliška Dastychová2, Ivana Kuklová3, Martina Kojanová3, Miluše Kreidlová4, Daniela Vaňousová5, Jana Hercogová5, Přemysl Procházka6, Hana Zákoucká7, Alena Krchňáková8, Vladimír Vašků2, David Šmajs9.   

Abstract

From January 2011 to December 2013, a total of 262 samples, from 188 patients suspected of having syphilis were tested for the presence of treponemal DNA by PCR amplification of five chromosomal loci, including the polA (TP0105), tmpC (TP0319), TP0136, TP0548, and 23S rRNA genes. Altogether, 146 samples from 103 patients were PCR positive for treponemal DNA. A set of 81 samples from 62 PCR-positive patients were typeable, and among them, nine different genotypes were identified. Compared to a previous study in the Czech Republic during 2004 to 2010, the number of genotypes detected among syphilis patients in a particular year increased to six in both 2012 and 2013, although they were not the same six. The proportion of macrolide-resistant clinical isolates in this 3-year study was 66.7%.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25100820      PMCID： PMC4187743          DOI： 10.1128/JCM.01292-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  37 in total

1.  A point mutation associated with bacterial macrolide resistance is present in both 23S rRNA genes of an erythromycin-resistant Treponema pallidum clinical isolate.

Authors:  L V Stamm; H L Bergen
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

2.  Clarithromycin resistance stability in Helicobacter pylori: influence of the MIC and type of mutation in the 23S rRNA.

Authors:  T Alarcón; D Domingo; N Prieto; M López-Brea
Journal:  J Antimicrob Chemother       Date:  2000-10       Impact factor: 5.790

3.  Macrolide resistance in Treponema pallidum in the United States and Ireland.

Authors:  Sheila A Lukehart; Charmie Godornes; Barbara J Molini; Patricia Sonnett; Susan Hopkins; Fiona Mulcahy; Joseph Engelman; Samuel J Mitchell; Anne M Rompalo; Christina M Marra; Jeffrey D Klausner
Journal:  N Engl J Med       Date:  2004-07-08       Impact factor: 91.245

4.  Azithromycin-resistant syphilis infection: San Francisco, California, 2000-2004.

Authors:  Samuel J Mitchell; Joseph Engelman; Charlotte K Kent; Sheila A Lukehart; Charmie Godornes; Jeffrey D Klausner
Journal:  Clin Infect Dis       Date:  2005-12-28       Impact factor: 9.079

5.  Use of the polymerase chain reaction to detect DNA sequences specific to pathogenic treponemes in cerebrospinal fluid.

Authors:  P E Hay; J R Clarke; R A Strugnell; D Taylor-Robinson; D Goldmeier
Journal:  FEMS Microbiol Lett       Date:  1990-03-15       Impact factor: 2.742

6.  In-vitro activity of azithromycin and CP-63,956 against Treponema pallidum.

Authors:  L V Stamm; E A Parrish
Journal:  J Antimicrob Chemother       Date:  1990-01       Impact factor: 5.790

7.  Molecular typing of Treponema pallidum in South Africa: cross-sectional studies.

Authors:  A Pillay; H Liu; S Ebrahim; C Y Chen; W Lai; G Fehler; R C Ballard; B Steiner; A W Sturm; S A Morse
Journal:  J Clin Microbiol       Date:  2002-01       Impact factor: 5.948

8.  Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification.

Authors:  P Goyette; J S Sumner; R Milos; A M Duncan; D S Rosenblatt; R G Matthews; R Rozen
Journal:  Nat Genet       Date:  1994-06       Impact factor: 38.330

9.  In vitro assay to demonstrate high-level erythromycin resistance of a clinical isolate of Treponema pallidum.

Authors:  L V Stamm; J T Stapleton; P J Bassford
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191

10.  Impact of azithromycin resistance mutations on the virulence and fitness of Chlamydia caviae in guinea pigs.

Authors:  Rachel Binet; Anne K Bowlin; Anthony T Maurelli; Roger G Rank
Journal:  Antimicrob Agents Chemother       Date:  2010-01-11       Impact factor: 5.191
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  27 in total

1.  The molecular epidemiology of Treponema pallidum subspecies pallidum.

Authors:  Daphne Y Ma; Lorenzo Giacani; Arturo Centurión-Lara
Journal:  Sex Health       Date:  2015-04       Impact factor: 2.706

2.  Enhanced Molecular Typing of Treponema pallidum subspecies pallidum Strains From 4 Italian Hospitals Shows Geographical Differences in Strain Type Heterogeneity, Widespread Resistance to Macrolides, and Lack of Mutations Associated With Doxycycline Resistance.

Authors:  Lorenzo Giacani; Giulia Ciccarese; Christian Puga-Salazar; Ivano Dal Conte; Laura Colli; Marco Cusini; Stefano Ramoni; Sergio Delmonte; Antonietta DʼAntuono; Valeria Gaspari; Francesco Drago
Journal:  Sex Transm Dis       Date:  2018-04       Impact factor: 2.830

3.  Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains?

Authors:  David Šmajs; Lenka Paštěková; Linda Grillová
Journal:  Am J Trop Med Hyg       Date:  2015-07-27       Impact factor: 2.345

Review 4.  Syphilis.

Authors:  Rosanna W Peeling; David Mabey; Mary L Kamb; Xiang-Sheng Chen; Justin D Radolf; Adele S Benzaken
Journal:  Nat Rev Dis Primers       Date:  2017-10-12       Impact factor: 52.329

5.  Circulation of Distinct Treponema pallidum Strains in Individuals with Heterosexual Orientation and Men Who Have Sex with Men.

Authors:  Yoko Kojima; Keiichi Furubayashi; Takuya Kawahata; Haruyo Mori; Jun Komano
Journal:  J Clin Microbiol       Date:  2019-01-02       Impact factor: 5.948

6.  Surveillance of Antibiotic Resistance Genes in Treponema Pallidum Subspecies Pallidum from Patients with Early Syphilis in France.

Authors:  Adrien Sanchez; Constance Mayslich; Isabelle Malet; Philippe Alain Grange; Michel Janier; Julie Saule; Pervenche Martinet; Jean-Luc Robert; Dominique Moulene; François Truchetet; Anne-Lise Pinault; Annie Vermersch-Langlin; Nadjet Benhaddou; Johan Chanal; Nicolas Dupin
Journal:  Acta Derm Venereol       Date:  2020-07-28       Impact factor: 3.875

7.  A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions.

Authors:  Darina Čejková; Michal Strouhal; Steven J Norris; George M Weinstock; David Šmajs
Journal:  PLoS Negl Trop Dis       Date:  2015-10-05

8.  Treponema pallidum Macrolide Resistance and Molecular Epidemiology in Southern Africa, 2008 to 2018.

Authors:  Johanna M E Venter; Etienne E Müller; Mahlape P Mahlangu; Ranmini S Kularatne
Journal:  J Clin Microbiol       Date:  2021-08-04       Impact factor: 5.948

9.  Penicillin Treatment Failure in Rabbit Syphilis Due to the Persistence of Treponemes (Treponema paraluisleporidarum Ecovar Cuniculus) in the Focus of Infection.

Authors:  Vladimír Jekl; Markéta Nováková; Edita Jeklová; Petra Pospíšilová; Jitka Křenová; Martin Faldyna; Miša Škorič; David Šmajs
Journal:  Front Vet Sci       Date:  2021-06-17

10.  Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains.

Authors:  Barbara J Molini; Lauren C Tantalo; Sharon K Sahi; Veronica I Rodriguez; Stephanie L Brandt; Mark C Fernandez; Charmie B Godornes; Christina M Marra; Sheila A Lukehart
Journal:  Sex Transm Dis       Date:  2016-09       Impact factor: 2.830
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