Literature DB >> 25100532

Stem cell aging: mechanisms, regulators and therapeutic opportunities.

Juhyun Oh1, Yang David Lee2, Amy J Wagers3.   

Abstract

Aging tissues experience a progressive decline in homeostatic and regenerative capacities, which has been attributed to degenerative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem cell activity. Understanding the molecular pathways involved in this age-dependent deterioration of stem cell function will be critical for developing new therapies for diseases of aging that target the specific causes of age-related functional decline. Here we explore key molecular pathways that are commonly perturbed as tissues and stem cells age and degenerate. We further consider experimental evidence both supporting and refuting the notion that modulation of these pathways per se can reverse aging phenotypes. Finally, we ask whether stem cell aging establishes an epigenetic 'memory' that is indelibly written or one that can be reset.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25100532      PMCID： PMC4160113          DOI： 10.1038/nm.3651

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  192 in total

1.  Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.

Authors:  Panagiota A Sotiropoulou; Aurélie Candi; Guilhem Mascré; Sarah De Clercq; Khalil Kass Youssef; Gaelle Lapouge; Ellen Dahl; Claudio Semeraro; Geertrui Denecker; Jean-Christophe Marine; Cédric Blanpain
Journal:  Nat Cell Biol       Date:  2010-05-16       Impact factor: 28.824

Review 2.  Linking functional decline of telomeres, mitochondria and stem cells during ageing.

Authors:  Ergün Sahin; Ronald A Depinho
Journal:  Nature       Date:  2010-03-25       Impact factor: 49.962

3.  AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

Authors:  Marisa M Juntilla; Vineet D Patil; Marco Calamito; Rohan P Joshi; Morris J Birnbaum; Gary A Koretzky
Journal:  Blood       Date:  2010-03-30       Impact factor: 22.113

4.  Altered histone acetylation is associated with age-dependent memory impairment in mice.

Authors:  Shahaf Peleg; Farahnaz Sananbenesi; Athanasios Zovoilis; Susanne Burkhardt; Sanaz Bahari-Javan; Roberto Carlos Agis-Balboa; Perla Cota; Jessica Lee Wittnam; Andreas Gogol-Doering; Lennart Opitz; Gabriella Salinas-Riester; Markus Dettenhofer; Hui Kang; Laurent Farinelli; Wei Chen; André Fischer
Journal:  Science       Date:  2010-05-07       Impact factor: 47.728

5.  Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1.

Authors:  Roman V Kondratov; Olena Vykhovanets; Anna A Kondratova; Marina P Antoch
Journal:  Aging (Albany NY)       Date:  2009-12-30       Impact factor: 5.682

6.  Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks.

Authors:  Brian D Larsen; Shravanti Rampalli; Leanne E Burns; Steve Brunette; F Jeffrey Dilworth; Lynn A Megeney
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-16       Impact factor: 11.205

7.  SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.

Authors:  Hyun-Seok Kim; Krish Patel; Kristi Muldoon-Jacobs; Kheem S Bisht; Nukhet Aykin-Burns; J Daniel Pennington; Riet van der Meer; Phuongmai Nguyen; Jason Savage; Kjerstin M Owens; Athanassios Vassilopoulos; Ozkan Ozden; Seong-Hoon Park; Keshav K Singh; Sarki A Abdulkadir; Douglas R Spitz; Chu-Xia Deng; David Gius
Journal:  Cancer Cell       Date:  2010-01-19       Impact factor: 31.743

8.  Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.

Authors:  Aaron W B Joe; Lin Yi; Anuradha Natarajan; Fabien Le Grand; Leslie So; Joy Wang; Michael A Rudnicki; Fabio M V Rossi
Journal:  Nat Cell Biol       Date:  2010-01-17       Impact factor: 28.824

Review 9.  The senescence-associated secretory phenotype: the dark side of tumor suppression.

Authors:  Jean-Philippe Coppé; Pierre-Yves Desprez; Ana Krtolica; Judith Campisi
Journal:  Annu Rev Pathol       Date:  2010       Impact factor: 23.472

10.  Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans.

Authors:  Eric L Greer; Travis J Maures; Anna G Hauswirth; Erin M Green; Dena S Leeman; Géraldine S Maro; Shuo Han; Max R Banko; Or Gozani; Anne Brunet
Journal:  Nature       Date:  2010-06-16       Impact factor: 49.962
View more
  240 in total

Review 1.  Regenerative medicine: Current therapies and future directions.

Authors:  Angelo S Mao; David J Mooney
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-24       Impact factor: 11.205

Review 2.  The DNA damage-induced cell death response: a roadmap to kill cancer cells.

Authors:  Sonja Matt; Thomas G Hofmann
Journal:  Cell Mol Life Sci       Date:  2016-01-20       Impact factor: 9.261

Review 3.  Accumulation of DNA damage in the aged hematopoietic stem cell compartment.

Authors:  Isabel Beerman
Journal:  Semin Hematol       Date:  2016-11-18       Impact factor: 3.851

Review 4.  A synopsis on aging-Theories, mechanisms and future prospects.

Authors:  João Pinto da Costa; Rui Vitorino; Gustavo M Silva; Christine Vogel; Armando C Duarte; Teresa Rocha-Santos
Journal:  Ageing Res Rev       Date:  2016-06-25       Impact factor: 10.895

Review 5.  Stem cell therapy for neurological disorders: A focus on aging.

Authors:  Hung Nguyen; Sydney Zarriello; Alexandreya Coats; Cannon Nelson; Chase Kingsbury; Anna Gorsky; Mira Rajani; Elliot G Neal; Cesar V Borlongan
Journal:  Neurobiol Dis       Date:  2018-09-13       Impact factor: 5.996

Review 6.  Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.

Authors:  Joana Neves; Pedro Sousa-Victor; Heinrich Jasper
Journal:  Cell Stem Cell       Date:  2017-02-02       Impact factor: 24.633

Review 7.  Mitochondrial maintenance failure in aging and role of sexual dimorphism.

Authors:  John Tower
Journal:  Arch Biochem Biophys       Date:  2014-10-25       Impact factor: 4.013

Review 8.  Gingival wound healing: an essential response disturbed by aging?

Authors:  P C Smith; M Cáceres; C Martínez; A Oyarzún; J Martínez
Journal:  J Dent Res       Date:  2014-12-19       Impact factor: 6.116

Review 9.  Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease.

Authors:  Isabel Beerman; Derrick J Rossi
Journal:  Cell Stem Cell       Date:  2015-06-04       Impact factor: 24.633

10.  Klotho Deficiency Accelerates Stem Cells Aging by Impairing Telomerase Activity.

Authors:  Mujib Ullah; Zhongjie Sun
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2019-08-16       Impact factor: 6.053
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.