Adrienne Dow1, Ruth Virginia Russell2, Vivien Bonert2, John Carmichael2, Adam Mamelak3, Barry D Pressman4, Xuemo Fan5, Run Yu2. 1. Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California. 2. Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California. 3. Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California. 4. Department of Imaging, Cedars Sinai Medical Center, Los Angeles, California. 5. Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.
Abstract
OBJECTIVE: Our objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis. METHODS: This is a case report. RESULTS: Despite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline. To our knowledge, there is no other reported case of lymphocytic hypophysitis with autoimmune inflammation extending beyond the infundibulum. CONCLUSION: This case broadens the clinical spectrum of lymphocytic hypophysitis.
OBJECTIVE: Our objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis. METHODS: This is a case report. RESULTS: Despite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline. To our knowledge, there is no other reported case of lymphocytic hypophysitis with autoimmune inflammation extending beyond the infundibulum. CONCLUSION: This case broadens the clinical spectrum of lymphocytic hypophysitis.