Literature DB >> 25100057

Control of gluconeogenesis by metformin: does redox trump energy charge?

Joseph A Baur1, Morris J Birnbaum2.   

Abstract

Metformin is the most widely prescribed drug to lower glucose in type II diabetics, yet its mechanism of action remains controversial. A new study reveals that metformin inhibits mitochondrial glycerol-3-phosphate dehydrogenase, triggering reduction of the cytosolic NADH/NAD(+) pool and impaired utilization of redox-dependent substrates for gluconeogenesis (Madiraju et al., 2014).
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25100057      PMCID： PMC4154964          DOI： 10.1016/j.cmet.2014.07.013

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.

Authors:  M R Owen; E Doran; A P Halestrap
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

2.  Effects of guanidine derivatives on mitochondrial function. 3. The mechanism of phenethylbiguanide accumulation and its relationship to in vitro respiratory inhibition.

Authors:  F Davidoff
Journal:  J Biol Chem       Date:  1971-06-25       Impact factor: 5.157

3.  Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.

Authors:  Marc Foretz; Sophie Hébrard; Jocelyne Leclerc; Elham Zarrinpashneh; Maud Soty; Gilles Mithieux; Kei Sakamoto; Fabrizio Andreelli; Benoit Viollet
Journal:  J Clin Invest       Date:  2010-06-23       Impact factor: 14.808

4.  Role of AMP-activated protein kinase in mechanism of metformin action.

Authors:  G Zhou; R Myers; Y Li; Y Chen; X Shen; J Fenyk-Melody; M Wu; J Ventre; T Doebber; N Fujii; N Musi; M F Hirshman; L J Goodyear; D E Moller
Journal:  J Clin Invest       Date:  2001-10       Impact factor: 14.808

5.  Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.

Authors:  Simon A Hawley; Fiona A Ross; Cyrille Chevtzoff; Kevin A Green; Ashleigh Evans; Sarah Fogarty; Mhairi C Towler; Laura J Brown; Oluseye A Ogunbayo; A Mark Evans; D Grahame Hardie
Journal:  Cell Metab       Date:  2010-06-09       Impact factor: 27.287

6.  Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency.

Authors:  Takeyori Saheki; Mikio Iijima; Meng Xian Li; Keiko Kobayashi; Masahisa Horiuchi; Miharu Ushikai; Fumihiko Okumura; Xiao Jian Meng; Ituro Inoue; Atsushi Tajima; Mitsuaki Moriyama; Kazuhiro Eto; Takashi Kadowaki; David S Sinasac; Lap-Chee Tsui; Mihoko Tsuji; Akira Okano; Tsuyoshi Kobayashi
Journal:  J Biol Chem       Date:  2007-06-25       Impact factor: 5.157

7.  Control of reversible intracellular transfer of reducing potential.

Authors:  W S Kunz; E J Davis
Journal:  Arch Biochem Biophys       Date:  1991-01       Impact factor: 4.013

8.  Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.

Authors:  Russell A Miller; Qingwei Chu; Jianxin Xie; Marc Foretz; Benoit Viollet; Morris J Birnbaum
Journal:  Nature       Date:  2013-01-06       Impact factor: 49.962

9.  Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.

Authors:  Anila K Madiraju; Derek M Erion; Yasmeen Rahimi; Xian-Man Zhang; Demetrios T Braddock; Ronald A Albright; Brett J Prigaro; John L Wood; Sanjay Bhanot; Michael J MacDonald; Michael J Jurczak; Joao-Paulo Camporez; Hui-Young Lee; Gary W Cline; Varman T Samuel; Richard G Kibbey; Gerald I Shulman
Journal:  Nature       Date:  2014-05-21       Impact factor: 49.962

10.  Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

Authors:  Morgan D Fullerton; Sandra Galic; Katarina Marcinko; Sarah Sikkema; Thomas Pulinilkunnil; Zhi-Ping Chen; Hayley M O'Neill; Rebecca J Ford; Rengasamy Palanivel; Matthew O'Brien; D Grahame Hardie; S Lance Macaulay; Jonathan D Schertzer; Jason R B Dyck; Bryce J van Denderen; Bruce E Kemp; Gregory R Steinberg
Journal:  Nat Med       Date:  2013-11-03       Impact factor: 53.440
  10 in total
  31 in total

1.  Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate.

Authors:  Cornelius von Morze; Michael A Ohliger; Irene Marco-Rius; David M Wilson; Robert R Flavell; David Pearce; Daniel B Vigneron; John Kurhanewicz; Zhen J Wang
Journal:  Magn Reson Med       Date:  2018-01-03       Impact factor: 4.668

2.  Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.

Authors:  Daniel M Rotroff; Sook Wah Yee; Kaixin Zhou; Skylar W Marvel; Hetal S Shah; John R Jack; Tammy M Havener; Monique M Hedderson; Michiaki Kubo; Mark A Herman; He Gao; Josyf C Mychaleckyi; Howard L McLeod; Alessandro Doria; Kathleen M Giacomini; Ewan R Pearson; Michael J Wagner; John B Buse; Alison A Motsinger-Reif
Journal:  Diabetes       Date:  2018-04-12       Impact factor: 9.461

Review 3.  Metformin as an Anticancer Agent.

Authors:  Ales Vancura; Pengli Bu; Madhura Bhagwat; Joey Zeng; Ivana Vancurova
Journal:  Trends Pharmacol Sci       Date:  2018-08-24       Impact factor: 14.819

4.  TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic Gluconeogenesis.

Authors:  Hariom Yadav; Samir Devalaraja; Stephanie T Chung; Sushil G Rane
Journal:  J Biol Chem       Date:  2017-01-09       Impact factor: 5.157

5.  Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate.

Authors:  Adam Neal; Austin M Rountree; Craig W Philips; Terrance J Kavanagh; Dominic P Williams; Peter Newham; Gamal Khalil; Daniel L Cook; Ian R Sweet
Journal:  Toxicol Sci       Date:  2015-09-22       Impact factor: 4.849

6.  Acute renal metabolic effect of metformin assessed with hyperpolarised MRI in rats.

Authors:  Haiyun Qi; Per M Nielsen; Marie Schroeder; Lotte B Bertelsen; Fredrik Palm; Christoffer Laustsen
Journal:  Diabetologia       Date:  2017-09-21       Impact factor: 10.122

Review 7.  Metformin and Breast Cancer: Molecular Targets.

Authors:  J Faria; G Negalha; A Azevedo; F Martel
Journal:  J Mammary Gland Biol Neoplasia       Date:  2019-03-22       Impact factor: 2.673

Review 8.  Metformin: A Hopeful Promise in Aging Research.

Authors:  Marta G Novelle; Ahmed Ali; Carlos Diéguez; Michel Bernier; Rafael de Cabo
Journal:  Cold Spring Harb Perspect Med       Date:  2016-03-01       Impact factor: 6.915

Review 9.  Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up.

Authors:  Rushika M Perera; Nabeel Bardeesy
Journal:  Cancer Discov       Date:  2015-11-03       Impact factor: 39.397

10.  Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.

Authors:  Ahmed Alshawi; Loranne Agius
Journal:  J Biol Chem       Date:  2018-12-27       Impact factor: 5.157
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