OBJECTIVE: Dyslipidemia contributes to the increased risk of cardiovascular disease in persons with type 1 diabetes (T1D). Weight control is commonly recommended as a treatment for dyslipidemia. However, the extent to which decreases in weight affect the lipid profile in youth with T1D is not known. Therefore, we tested the hypothesis that decreases in body mass index z-score (BMIz) were associated with concomitant changes in the lipid profile in youth with T1D. STUDY DESIGN: We studied 1142 youth with incident T1D, who had at least two fasting lipid measurements over 2 yr (initial visit mean: age = 10.8 ± 3.9 yr, BMIz = 0.55 ± 0.97, T1D duration = 10.7 ± 7.6 months; 47.5% female, 77.9% non-Hispanic white) in the SEARCH for Diabetes in Youth Study. Longitudinal mixed models were used to examine the relationships between changes in BMIz and changes in total, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL cholesterol, and log triglycerides (TG) adjusted for initial age, sex, race/ethnicity, clinical site, season of study visit, T1D duration, and glycated hemoglobin A1c (HbA1c). RESULTS: We found that over 2 yr all lipid levels, except LDL-C, increased significantly (p < 0.05). Decreases in BMIz were associated with favorable changes in HDL-C and TG only and the magnitude of these changes depended on the initial BMIz value (interaction p < 0.05), so that greater improvements were seen in those with higher BMIz. CONCLUSIONS: Our data suggest that weight loss may be an effective, but limited, therapeutic approach for dyslipidemia in youth with T1D.
OBJECTIVE: Dyslipidemia contributes to the increased risk of cardiovascular disease in persons with type 1 diabetes (T1D). Weight control is commonly recommended as a treatment for dyslipidemia. However, the extent to which decreases in weight affect the lipid profile in youth with T1D is not known. Therefore, we tested the hypothesis that decreases in body mass index z-score (BMIz) were associated with concomitant changes in the lipid profile in youth with T1D. STUDY DESIGN: We studied 1142 youth with incident T1D, who had at least two fasting lipid measurements over 2 yr (initial visit mean: age = 10.8 ± 3.9 yr, BMIz = 0.55 ± 0.97, T1D duration = 10.7 ± 7.6 months; 47.5% female, 77.9% non-Hispanic white) in the SEARCH for Diabetes in Youth Study. Longitudinal mixed models were used to examine the relationships between changes in BMIz and changes in total, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL cholesterol, and log triglycerides (TG) adjusted for initial age, sex, race/ethnicity, clinical site, season of study visit, T1D duration, and glycated hemoglobin A1c (HbA1c). RESULTS: We found that over 2 yr all lipid levels, except LDL-C, increased significantly (p < 0.05). Decreases in BMIz were associated with favorable changes in HDL-C and TG only and the magnitude of these changes depended on the initial BMIz value (interaction p < 0.05), so that greater improvements were seen in those with higher BMIz. CONCLUSIONS: Our data suggest that weight loss may be an effective, but limited, therapeutic approach for dyslipidemia in youth with T1D.
Authors: Janet Silverstein; Georgeanna Klingensmith; Kenneth Copeland; Leslie Plotnick; Francine Kaufman; Lori Laffel; Larry Deeb; Margaret Grey; Barbara Anderson; Lea Ann Holzmeister; Nathaniel Clark Journal: Diabetes Care Date: 2005-01 Impact factor: 19.112
Authors: D S Freedman; G L Burke; D W Harsha; S R Srinivasan; J L Cresanta; L S Webber; G S Berenson Journal: JAMA Date: 1985-07-26 Impact factor: 56.272
Authors: Mikko J Järvisalo; Anne Putto-Laurila; Laura Jartti; Terho Lehtimäki; Tiina Solakivi; Tapani Rönnemaa; Olli T Raitakari Journal: Diabetes Date: 2002-02 Impact factor: 9.461
Authors: K Otfried Schwab; Jürgen Doerfer; Wolfgang Hecker; Jürgen Grulich-Henn; Dagobert Wiemann; Olga Kordonouri; Peter Beyer; Reinhard W Holl Journal: Diabetes Care Date: 2006-02 Impact factor: 19.112
Authors: Angel S Y Nip; Beth A Reboussin; Dana Dabelea; Anna Bellatorre; Elizabeth J Mayer-Davis; Anna R Kahkoska; Jean M Lawrence; Claire M Peterson; Lawrence Dolan; Catherine Pihoker Journal: Diabetes Care Date: 2019-03-12 Impact factor: 17.152
Authors: Amy S Shah; David M Maahs; Jeanette M Stafford; Lawrence M Dolan; Wei Lang; Giuseppina Imperatore; Ronny A Bell; Angela D Liese; Kristi Reynolds; Catherine Pihoker; Santica Marcovina; Ralph B D'Agostino; Dana Dabelea Journal: Diabetes Care Date: 2017-01-26 Impact factor: 19.112
Authors: Evgenia Gourgari; Jeanette M Stafford; Ralph D'Agostino; Lawrence M Dolan; Jean M Lawrence; Amy Mottl; Catherine Pihoker; Elaine M Urbina; R Paul Wadwa; Dana Dabelea Journal: Ann Pediatr Endocrinol Metab Date: 2019-09-30
Authors: Ryan P Brady; Amy S Shah; Elizabeth T Jensen; Jeanette M Stafford; Ralph B D'Agostino; Lawrence M Dolan; Lisa Knight; Giuseppina Imperatore; Christine B Turley; Angela D Liese; Elaine M Urbina; Jean M Lawrence; Catherine Pihoker; Santica Marcovina; Dana Dabelea Journal: Pediatr Diabetes Date: 2021-08-15 Impact factor: 4.866