Literature DB >> 2509944

Genetic engineering of factor VIII.

R J Kaufman1.   

Abstract

Genetic manipulation of mammalian cells has provided a means of producing unlimited quantities of a high purity, virus-free preparation of factor VIII--the most complex protein manufactured through rDNA technology to date.

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Year:  1989        PMID： 2509944     DOI： 10.1038/342207a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  6 in total

1.  Structural and functional characterization of Factor VIII-delta II, a new recombinant Factor VIII lacking most of the B-domain.

Authors:  N Bihoreau; P Paolantonacci; C Bardelle; M P Fontaine-Aupart; S Krishnan; J Yon; J L Romet-Lemonne
Journal:  Biochem J       Date:  1991-07-01       Impact factor: 3.857

2.  Enhanced secretory ability for the human factor VIII light chain produced in baculovirus-infected insect cells.

Authors:  E Webb; J Tkalcevic; S Edwards; D Hocking; I Nisbet
Journal:  Cytotechnology       Date:  1996       Impact factor: 2.058

Review 3.  Platelet and endothelial expression of clotting factors for the treatment of hemophilia.

Authors:  Robert R Montgomery; Qizhen Shi
Journal:  Thromb Res       Date:  2012-03-14       Impact factor: 3.944

4.  Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep.

Authors:  H Niemann; R Halter; J W Carnwath; D Herrmann; E Lemme; D Paul
Journal:  Transgenic Res       Date:  1999-06       Impact factor: 2.788

5.  The enhancing effects of the light chain on heavy chain secretion in split delivery of factor VIII gene.

Authors:  Lingxia Chen; Fuxiang Zhu; Juan Li; Hui Lu; Haiyan Jiang; Rita Sarkar; Valder R Arruda; Jinhui Wang; Jennifer Zhao; Glenn F Pierce; Qiulan Ding; Xuefeng Wang; Hongli Wang; Steven W Pipe; Xiang-Qin Liu; Xiao Xiao; Rodney M Camire; Weidong Xiao
Journal:  Mol Ther       Date:  2007-07-24       Impact factor: 11.454

6.  Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum.

Authors:  Juthakorn Poothong; Anita Pottekat; Marina Siirin; Alexandre Rosa Campos; Adrienne W Paton; James C Paton; Jacqueline Lagunas-Acosta; Zhouji Chen; Mark Swift; Niels Volkmann; Dorit Hanein; Jing Yong; Randal J Kaufman
Journal:  Blood       Date:  2020-05-21       Impact factor: 25.476
  6 in total

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