| Literature DB >> 25099026 |
Yajun Wang1, Andrew K Wise, Justin Tan, James W Maina, Robert K Shepherd, Frank Caruso.
Abstract
Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS-SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS-SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model.Entities:
Keywords: drug delivery; mesoporous materials; neurotrophic factors; sensorineural hearing loss; supraparticles
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Year: 2014 PMID: 25099026 DOI: 10.1002/smll.201401767
Source DB: PubMed Journal: Small ISSN: 1613-6810 Impact factor: 13.281