| Literature DB >> 25098433 |
Xiaolong Wei1, Chunfa Chen, Didi Xi, Jinwen Bai, Wenhe Huang, Luoxiang Rong, Mingyao Wu, Guojun Zhang.
Abstract
Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial response based on RECIST criteria) and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.Entities:
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Year: 2014 PMID： 25098433 DOI： 10.1007/s11684-014-0345-z
Source DB: PubMed Journal: Front Med ISSN： 2095-0217 Impact factor: 4.592