Mahdieh Khadem Haghighian1, Beitollah Alipoor2, Bina Eftekhar Sadat3, Aida Malek Mahdavi1, Abdolvahab Moghaddam3, Amir-Mansour Vatankhah4. 1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. 2. Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. 3. Department of Physical Medicine and Rehabilitation, Tabriz University of Medical Sciences, Tabriz, Iran. 4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
BACKGROUND: This study was designed to assess the effect of sesame seed on lipid profile and oxidative stress biomarkers in knee osteoarthritis (OA) patients. METHODS:Fifty patients with knee OA were allocated into two groups receiving 40 g of sesame seed daily along with standard medical therapy (n=25) or stan-dard treatment (n=25) for two months. Serum total antioxidant capacity, ma-londialdehyde (MDA) and lipid profile (total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides) were measured. RESULTS: After the intervention period two months of study, serum TC, LDL-cholesterol and MDA decreased significantly in the sesame group (P<0.05), while no significant difference in serum values of lipid profile andoxidative stress parameters was seen in the control group (P>0.05). There was no signifi-cant difference in pre and post-treatment values of lipid profile and oxidative parameters between the two groups (P>0.05). CONCLUSION: Current study showed a positive effect of sesame seed in improv-ing lipid profile and oxidative stress in patients with knee OA and indicated the fact that sesame seed might be of help to reduce oxidative stress in OA patients.
RCT Entities:
BACKGROUND: This study was designed to assess the effect of sesame seed on lipid profile and oxidative stress biomarkers in knee osteoarthritis (OA) patients. METHODS: Fifty patients with knee OA were allocated into two groups receiving 40 g of sesame seed daily along with standard medical therapy (n=25) or stan-dard treatment (n=25) for two months. Serum total antioxidant capacity, ma-londialdehyde (MDA) and lipid profile (total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides) were measured. RESULTS: After the intervention period two months of study, serum TC, LDL-cholesterol and MDA decreased significantly in the sesame group (P<0.05), while no significant difference in serum values of lipid profile and oxidative stress parameters was seen in the control group (P>0.05). There was no signifi-cant difference in pre and post-treatment values of lipid profile and oxidative parameters between the two groups (P>0.05). CONCLUSION: Current study showed a positive effect of sesame seed in improv-ing lipid profile and oxidative stress in patients with knee OA and indicated the fact that sesame seed might be of help to reduce oxidative stress in OA patients.
Authors: Gregory Livshits; Guangju Zhai; Deborah J Hart; Bernet S Kato; Huizhong Wang; Frances M K Williams; Tim D Spector Journal: Arthritis Rheum Date: 2009-07