| Literature DB >> 2509732 |
K Odensvik1, N Cort, S Basu, H Kindahl.
Abstract
The effect of flunixin meglumine on prostaglandin synthesis and metabolism was evaluated in the pig in vivo. It was found that the prostaglandin metabolite, 15-ketodihydro-PGF2 alpha, was decreased in the peripheral circulation within 20 min of injection of the drug. In therapeutic doses in the pig the drug had no effect on the metabolism of PGF2 alpha. Flunixin was compared with some other non-steroidal anti-inflammatory drugs in an in vitro test system utilizing sheep vesicular gland microsomes. It was concluded that this drug is a potent inhibitor of prostaglandin synthesis.Entities:
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Year: 1989 PMID： 2509732 DOI： 10.1111/j.1365-2885.1989.tb00676.x
Source DB: PubMed Journal: J Vet Pharmacol Ther ISSN： 0140-7783 Impact factor: 1.786