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Literature DB >> 25096

Effects of ammonium and bicarbonate-CO2 on intracellular chloride levels in Aplysia neurons.

Abstract

The level of intracellular free chloride in Aplysia giant neurons can be made to decline by pretreatment with 50 mM NH4+ solution followed by washing with 10 mM HCO3-/0.4% CO2-containing fluids. This effect can be completely blocked by the anion flux inhibitor, 4-acetamido-4'-isothiocyano-stilbene-2,2'-disulfonic acid (SITS). The net change of free chloride in the cell cannot be explained by changes in the electrochemical gradient of chloride. These results support the hypothesis that at least one mechanism for intracellular pH regulation involves a Cl-/HCO-3 exchange process.

Entities: Chemical

Mesh：

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Year: 1978 PMID： 25096 PMCID： PMC1473400 DOI： 10.1016/S0006-3495(78)85478-2

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

10 in total

5. The nature of the membrane sites controlling anion permeability of human red blood cells as determined by studies with disulfonic stilbene derivatives.

Authors: Z I Cabantchik; A Rothstein
Journal: J Membr Biol Date: 1972-12-29 Impact factor: 1.843

6 in total

1. The role of intracellular chloride in hyperpolarizing post-synaptic inhibition of crayfish stretch receptor neurones.

Authors: R A Deisz; H D Lux
Journal: J Physiol Date: 1982-05 Impact factor: 5.182

2. Chloride distribution in the proximal convoluted tubule of Necturus kidney.

Authors: A Edelman; M Bouthier; T Anagnostopoulos
Journal: J Membr Biol Date: 1981 Impact factor: 1.843

3. Ammonium action on post-synaptic inhibition in crayfish neurones: implications for the mechanism of chloride extrusion.

Authors: C C Aickin; R A Deisz; H D Lux
Journal: J Physiol Date: 1982-08 Impact factor: 5.182

Effects of ammonium and bicarbonate-CO2 on intracellular chloride levels in Aplysia neurons.

1. Active proton transport stimulated by CO2/HCO3-, blocked by cyanide.

2. Role of choloride transport in regulation of intracellular pH.

3. Studies on the internal pH of large muscle and nerve fibres.

4. Blockage of inhibition by ammonium acetate action on chloride pump in cat trochlear motoneurons.

5. The nature of the membrane sites controlling anion permeability of human red blood cells as determined by studies with disulfonic stilbene derivatives.

6. Ammonium and chloride extrusion: hyperpolarizing synaptic inhibition in spinal motoneurons.

7. Effects of 4-acetamido-4'-isothiocyano-2,2-disulfonic stilbene on ion transport in turtle bladders.

8. Intracellular pH of snail neurones measured with a new pH-sensitive glass mirco-electrode.

9. Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors.

10. Active transport of chloride by the giant neuron of the Aplysia abdominal ganglion.

1. The role of intracellular chloride in hyperpolarizing post-synaptic inhibition of crayfish stretch receptor neurones.

2. Chloride distribution in the proximal convoluted tubule of Necturus kidney.

3. Ammonium action on post-synaptic inhibition in crayfish neurones: implications for the mechanism of chloride extrusion.

4. Stimulation of Na:H exchange by insulin.

5. Bicarbonate and fast-twitch muscle: evidence for a major role in pH regulation.

6. Properties of chloride transport in barnacle muscle fibers.