| Literature DB >> 25092800 |
William C Hwang1, Qingping Xu, Bainan Wu, Adam Godzik.
Abstract
Flavin-containing Monooxygenase (FMO) catalyzed the oxygenation of broad spectrum of substrates. FMO can also serve as biocatalysts in the Baeyer-Villiger reaction in organic synthesis. Here, we report the high-resolution crystal structure of a Baeyer-Villiger Flavin-containing Monooxygenase (BVFMO) from methicillin- and vancomycin-resistant Staphylococcus aureus strain MU50. The structure of S. aureus FMO should facilitate further development of BVFMO as biocatalysts. A possible role of S. aureus FMO in methicillin and vancomycin resistance is discussed.Keywords: Baeyer-Villiger reaction; FMO; antibiotics resistance; methicillin; vancomycin
Year: 2014 PMID: 25092800 DOI: 10.1002/prot.24661
Source DB: PubMed Journal: Proteins ISSN: 0887-3585