Literature DB >> 25092800

Retracted: Crystal structure of a Baeyer-Villiger flavin-containing monooxygenase from Staphylococcus aureus MRSA strain MU50.

William C Hwang1, Qingping Xu, Bainan Wu, Adam Godzik.   

Abstract

Flavin-containing Monooxygenase (FMO) catalyzed the oxygenation of broad spectrum of substrates. FMO can also serve as biocatalysts in the Baeyer-Villiger reaction in organic synthesis. Here, we report the high-resolution crystal structure of a Baeyer-Villiger Flavin-containing Monooxygenase (BVFMO) from methicillin- and vancomycin-resistant Staphylococcus aureus strain MU50. The structure of S. aureus FMO should facilitate further development of BVFMO as biocatalysts. A possible role of S. aureus FMO in methicillin and vancomycin resistance is discussed.
Copyright © 2014 Wiley Periodicals, Inc.

Keywords:  Baeyer-Villiger reaction; FMO; antibiotics resistance; methicillin; vancomycin

Year:  2014        PMID: 25092800     DOI: 10.1002/prot.24661

Source DB:  PubMed          Journal:  Proteins        ISSN: 0887-3585


  15 in total

1.  GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H... O hydrogen bonds and van der waals interactions.

Authors:  Gary Kleiger; David Eisenberg
Journal:  J Mol Biol       Date:  2002-10-11       Impact factor: 5.469

2.  TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics.

Authors:  Wangrong Yang; Ian F Moore; Kalinka P Koteva; David C Bareich; Donald W Hughes; Gerard D Wright
Journal:  J Biol Chem       Date:  2004-09-27       Impact factor: 5.157

Review 3.  Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts.

Authors:  W J H van Berkel; N M Kamerbeek; M W Fraaije
Journal:  J Biotechnol       Date:  2006-05-19       Impact factor: 3.307

Review 4.  Baeyer-Villiger monooxygenases: more than just green chemistry.

Authors:  Hannes Leisch; Krista Morley; Peter C K Lau
Journal:  Chem Rev       Date:  2011-05-04       Impact factor: 60.622

5.  The Arabidopsis flavin-dependent monooxygenase FMO1 is an essential component of biologically induced systemic acquired resistance.

Authors:  Tatiana E Mishina; Jürgen Zeier
Journal:  Plant Physiol       Date:  2006-06-15       Impact factor: 8.340

Review 6.  Human flavin-containing monooxygenases.

Authors:  John R Cashman; Jun Zhang
Journal:  Annu Rev Pharmacol Toxicol       Date:  2006       Impact factor: 13.820

7.  Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 Å resolution.

Authors:  Katarzyna Walkiewicz; Milya Davlieva; Gang Wu; Yousif Shamoo
Journal:  Proteins       Date:  2011-05-16

8.  Dali server: conservation mapping in 3D.

Authors:  Liisa Holm; Päivi Rosenström
Journal:  Nucleic Acids Res       Date:  2010-05-10       Impact factor: 16.971

9.  FFAS server: novel features and applications.

Authors:  Lukasz Jaroszewski; Zhanwen Li; Xiao-hui Cai; Christoph Weber; Adam Godzik
Journal:  Nucleic Acids Res       Date:  2011-07       Impact factor: 16.971

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