Zhenshun Cheng1, Rongli Ma2, Weijun Tan3, Li Zhang3, Qiuyue Tan3. 1. Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, China chzs1990_2@163.com. 2. First Department of Cadres Ward, Wuhan General Hospital of Guangzhou Military Command of PLA, China. 3. Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, China.
Abstract
OBJECTIVE: Previous case-control studies on the relation between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and lung cancer were controversial. In this study, we aimed to further evaluate the relation between the ACE gene I/D polymorphism and lung cancer. METHODS: We selected eight case-control studies related to the ACE gene I/D polymorphism and lung cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized Q-test and I (2) test to test the heterogeneity between each study. To merge the odds ratio (OR) and 95% confidence interval, we utilized the fixed-effects model during the analyses. RESULTS: The present study included 1612 patients with lung cancer and 1442 cancer-free control subjects. By meta-analysis, we did not find any association between the ACE gene I/D polymorphism and lung cancer in either genotype or allele distribution (DD vs. (ID+II): OR = 0.96, 95% CI (0.80-1.14), p = 0. 61; D allele vs. I allele: OR = 1.01, 95% CI (0.91-1.13), p = 0.79). CONCLUSION: We concluded that the ACE gene I/D polymorphism was not associated with lung cancer.
OBJECTIVE: Previous case-control studies on the relation between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and lung cancer were controversial. In this study, we aimed to further evaluate the relation between the ACE gene I/D polymorphism and lung cancer. METHODS: We selected eight case-control studies related to the ACE gene I/D polymorphism and lung cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized Q-test and I (2) test to test the heterogeneity between each study. To merge the odds ratio (OR) and 95% confidence interval, we utilized the fixed-effects model during the analyses. RESULTS: The present study included 1612 patients with lung cancer and 1442 cancer-free control subjects. By meta-analysis, we did not find any association between the ACE gene I/D polymorphism and lung cancer in either genotype or allele distribution (DD vs. (ID+II): OR = 0.96, 95% CI (0.80-1.14), p = 0. 61; D allele vs. I allele: OR = 1.01, 95% CI (0.91-1.13), p = 0.79). CONCLUSION: We concluded that the ACE gene I/D polymorphism was not associated with lung cancer.