Literature DB >> 25092704

Agmatine-containing poly(amidoamine)s as a novel class of antiviral macromolecules: structural properties and in vitro evaluation of infectivity inhibition.

Manuela Donalisio1, Elisabetta Ranucci2, Valeria Cagno1, Andrea Civra1, Amedea Manfredi2, Roberta Cavalli3, Paolo Ferruti2, David Lembo4.   

Abstract

Poly(amidoamine)s (PAAs) are multifunctional tert-amine polymers endowed with high structural versatility. Here we report on the screening of a minilibrary of PAAs against a panel of viruses. The PAA AGMA1 showed antiviral activity against herpes simplex virus, human cytomegalovirus, human papillomavirus 16, and respiratory syncytial virus but not against human rotavirus and vesicular stomatitis virus. The results suggest the contribution of both a polycationic nature and side guanidine groups in imparting antiviral activity.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25092704      PMCID： PMC4187951          DOI： 10.1128/AAC.03420-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Characterization of the inhibition of enveloped virus infectivity by the cationic acrylate polymer eudragit E100.

Authors:  Roxana V Alasino; Ismael D Bianco; María S Vitali; Jorge A Zarzur; Dante M Beltramo
Journal:  Macromol Biosci       Date:  2007-09-11       Impact factor: 4.979

2.  Evidence for the role of proteoglycans in cation-mediated gene transfer.

Authors:  K A Mislick; J D Baldeschwieler
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

3.  Initial interaction of herpes simplex virus with cells is binding to heparan sulfate.

Authors:  D WuDunn; P G Spear
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

4.  Amphipathic and membrane-destabilizing properties of the cationic acrylate polymer Eudragit E100.

Authors:  Roxana V Alasino; Salvador F Ausar; Ismael D Bianco; Leonardo F Castagna; Marta Contigiani; Dante M Beltramo
Journal:  Macromol Biosci       Date:  2005-03-15       Impact factor: 4.979

5.  Prevailingly cationic agmatine-based amphoteric polyamidoamine as a nontoxic, nonhemolytic, and "stealthlike" DNA complexing agent and transfection promoter.

Authors:  Paolo Ferruti; Jacopo Franchini; Marco Bencini; Elisabetta Ranucci; Gian Paolo Zara; Loredana Serpe; Luca Primo; Roberta Cavalli
Journal:  Biomacromolecules       Date:  2007-03-28       Impact factor: 6.988

6.  The L1 major capsid protein of human papillomavirus type 11 recombinant virus-like particles interacts with heparin and cell-surface glycosaminoglycans on human keratinocytes.

Authors:  J G Joyce; J S Tung; C T Przysiecki; J C Cook; E D Lehman; J A Sands; K U Jansen; P M Keller
Journal:  J Biol Chem       Date:  1999-02-26       Impact factor: 5.157

Review 7.  Sulfated K5 Escherichia coli polysaccharide derivatives: A novel class of candidate antiviral microbicides.

Authors:  Marco Rusnati; Elisa Vicenzi; Manuela Donalisio; Pasqua Oreste; Santo Landolfo; David Lembo
Journal:  Pharmacol Ther       Date:  2009-05-14       Impact factor: 12.310

8.  A human cytomegalovirus glycoprotein complex designated gC-II is a major heparin-binding component of the envelope.

Authors:  B Kari; R Gehrz
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103

Review 9.  Cell-surface proteoglycans as molecular portals for cationic peptide and polymer entry into cells.

Authors:  G M K Poon; J Gariépy
Journal:  Biochem Soc Trans       Date:  2007-08       Impact factor: 5.407

10.  Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells.

Authors:  Ada Funaro; Giorgio Gribaudo; Anna Luganini; Erika Ortolan; Nicola Lo Buono; Elisa Vicenzi; Luca Cassetta; Santo Landolfo; Richard Buick; Luca Falciola; Marianne Murphy; Gianni Garotta; Fabio Malavasi
Journal:  BMC Biotechnol       Date:  2008-11-12       Impact factor: 2.563
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  6 in total

1.  The agmatine-containing poly(amidoamine) polymer AGMA1 binds cell surface heparan sulfates and prevents attachment of mucosal human papillomaviruses.

Authors:  Valeria Cagno; Manuela Donalisio; Antonella Bugatti; Andrea Civra; Roberta Cavalli; Elisabetta Ranucci; Paolo Ferruti; Marco Rusnati; David Lembo
Journal:  Antimicrob Agents Chemother       Date:  2015-06-15       Impact factor: 5.191

2.  Antiviral activities of four marine sulfated glycans against adenovirus and human cytomegalovirus.

Authors:  Mary Zoepfl; Rohini Dwivedi; Maggie C Taylor; Vitor H Pomin; Michael A McVoy
Journal:  Antiviral Res       Date:  2021-04-14       Impact factor: 10.103

3.  Linear biocompatible glyco-polyamidoamines as dual action mode virus infection inhibitors with potential as broad-spectrum microbicides for sexually transmitted diseases.

Authors:  Nicolò Mauro; Paolo Ferruti; Elisabetta Ranucci; Amedea Manfredi; Angela Berzi; Mario Clerici; Valeria Cagno; David Lembo; Alessandro Palmioli; Sara Sattin
Journal:  Sci Rep       Date:  2016-09-19       Impact factor: 4.379

4.  High Temperature-Short Time Pasteurization Has a Lower Impact on the Antiviral Properties of Human Milk Than Holder Pasteurization.

Authors:  Manuela Donalisio; Massimo Rittà; Rachele Francese; Andrea Civra; Paola Tonetto; Alessandra Coscia; Marzia Giribaldi; Laura Cavallarin; Guido E Moro; Enrico Bertino; David Lembo
Journal:  Front Pediatr       Date:  2018-10-16       Impact factor: 3.418

Review 5.  Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?

Authors:  Valeria Cagno; Eirini D Tseligka; Samuel T Jones; Caroline Tapparel
Journal:  Viruses       Date:  2019-07-01       Impact factor: 5.048

Review 6.  Toward the prevention of coronavirus infection: what role can polymers play?

Authors:  X Jiang; Z Li; D J Young; M Liu; C Wu; Y-L Wu; X J Loh
Journal:  Mater Today Adv       Date:  2021-03-20
  6 in total

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