Tom W C Lung1, Dennis Petrie2, William H Herman3, Andrew J Palmer4, Ann-Marie Svensson5, Bjorn Eliasson5, Philip M Clarke2. 1. Centre for Health Policy, School of Population and Global Health, University of Melbourne, Melbourne, Australia tom.lung@unimelb.edu.au. 2. Centre for Health Policy, School of Population and Global Health, University of Melbourne, Melbourne, Australia. 3. Department of Internal Medicine, University of Michigan, Ann Arbor, MI. 4. Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia. 5. Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
Abstract
OBJECTIVE: To examine whether previous severe hypoglycemic events were associated with the risk of all-cause mortality after major cardiovascular events (myocardial infarction [MI] or stroke) in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: This study is based on data from the Swedish National Diabetes Register linked to patient-level hospital records, prescription data, and death records. We selected patients with type 1 diabetes who visited a clinic during 2002-2010 and experienced a major cardiovascular complication after their clinic visit. We estimated a two-part model for all-cause mortality after a major cardiovascular event: logistic regression for death within the first month and a Cox proportional hazards model conditional on 1-month survival. At age 60 years, 5-year cumulative mortality risk was estimated from the models for patients with and without prior diabetes complications. RESULTS: A total of 1,839 patients experienced major cardiovascular events, of whom 403 had previously experienced severe hypoglycemic events and 703 died within our study period. A prior hypoglycemic event was associated with a significant increase in mortality after a cardiovascular event, with hazard ratios estimated at 1.79 (95% CI 1.37-2.35) within the first month and 1.25 (95% CI 1.02-1.53) after 1 month. Patients with prior hypoglycemia had an estimated 5-year cumulative mortality risk of 52.4% (95% CI 45.3-59.5) and 39.8% (95% CI 33.4-46.3) for MI and stroke, respectively. CONCLUSIONS: We have found evidence that patients with type 1 diabetes in Sweden with prior severe hypoglycemic events have increased risk of mortality after a cardiovascular event.
OBJECTIVE: To examine whether previous severe hypoglycemic events were associated with the risk of all-cause mortality after major cardiovascular events (myocardial infarction [MI] or stroke) in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: This study is based on data from the Swedish National Diabetes Register linked to patient-level hospital records, prescription data, and death records. We selected patients with type 1 diabetes who visited a clinic during 2002-2010 and experienced a major cardiovascular complication after their clinic visit. We estimated a two-part model for all-cause mortality after a major cardiovascular event: logistic regression for death within the first month and a Cox proportional hazards model conditional on 1-month survival. At age 60 years, 5-year cumulative mortality risk was estimated from the models for patients with and without prior diabetes complications. RESULTS: A total of 1,839 patients experienced major cardiovascular events, of whom 403 had previously experienced severe hypoglycemic events and 703 died within our study period. A prior hypoglycemic event was associated with a significant increase in mortality after a cardiovascular event, with hazard ratios estimated at 1.79 (95% CI 1.37-2.35) within the first month and 1.25 (95% CI 1.02-1.53) after 1 month. Patients with prior hypoglycemia had an estimated 5-year cumulative mortality risk of 52.4% (95% CI 45.3-59.5) and 39.8% (95% CI 33.4-46.3) for MI and stroke, respectively. CONCLUSIONS: We have found evidence that patients with type 1 diabetes in Sweden with prior severe hypoglycemic events have increased risk of mortality after a cardiovascular event.
Authors: Ashley Pinckney; Mark R Rigby; Lynette Keyes-Elstein; Carol L Soppe; Gerald T Nepom; Mario R Ehlers Journal: Clin Ther Date: 2016-05-18 Impact factor: 3.393
Authors: Dennis Petrie; Tom W C Lung; Aidin Rawshani; Andrew J Palmer; Ann-Marie Svensson; Björn Eliasson; Philip Clarke Journal: Diabetologia Date: 2016-04-05 Impact factor: 10.122
Authors: Isabelle Steineck; Jan Cederholm; Björn Eliasson; Araz Rawshani; Katarina Eeg-Olofsson; Ann-Marie Svensson; Björn Zethelius; Tarik Avdic; Mona Landin-Olsson; Johan Jendle; Soffia Gudbjörnsdóttir Journal: BMJ Date: 2015-06-22