| Literature DB >> 25092065 |
Tatyana N Makarieva1, Ekaterina K Ogurtsova, Vladimir A Denisenko, Pavel S Dmitrenok, Ksenya M Tabakmakher, Alla G Guzii, Evgeny A Pislyagin, Andrey A Es'kov, Valery B Kozhemyako, Dmitry L Aminin, Yun-Ming Wang, Valentin A Stonik.
Abstract
Urupocidins A and B (1 and 2), bisguanidine alkaloids with an unprecedented skeleton system, derived from polyketide precursors and containing an unusual N-alkyl-N-hydroxyguanidine moiety, have been isolated from the sponge Monanhora pulchra. The structures of 1 and 2, including absolute configuration, were established using the detailed analysis of 1D and 2D NMR, CD, and mass spectra as well as chemical transformations. Compound 1 increases nitric oxide production in murine macrophages via inducing iNOS expression.Entities:
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Year: 2014 PMID： 25092065 DOI： 10.1021/ol502013f
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005