Rajeev Zachariah Kompithra1, Anu Paul2, Divya Manoharan2, Sudhir Babji2, Rajiv Sarkar2, Leni G Mathew1, Gagandeep Kang3. 1. Department of Paediatrics, Christian Medical College, Vellore, India. 2. Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India. 3. Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India. Electronic address: gkang@cmcvellore.ac.in.
Abstract
AIM: This study was undertaken to compare the immunogenicity of a three dose and five dose schedule of an oral live-attenuated human rotavirus vaccine, Rotarixin south Indian infants. METHOD:Healthy infants (N=90), six to seven weeks of age were enrolled to receive three doses (n=45) or five doses of Rotarix vaccine (n=45) along with other scheduled vaccines, each dose separated by a four week interval. Blood samples were taken before vaccination and one month post-dose three in the Rotarix three dose group and one month post-dose five in the Rotarix five dose group; all were tested for anti-rotavirus IgA by an antibody sandwich enzyme immunoassay. RESULTS: At baseline, >50% of infants had >20 units of anti-rotavirus IgA. The seroconversion rates after three and five doses were low and not significantly different in the two groups. However, among vaccine responders, children seropositive at baseline showed a much greater absolute increase in IgA antibody levels than children seronegative at baseline. CONCLUSIONS:Rotarix vaccine showed low immunogenicity in south Indian children and increasing the number of doses did not increase the proportion of infants seroconverting after vaccination.
RCT Entities:
AIM: This study was undertaken to compare the immunogenicity of a three dose and five dose schedule of an oral live-attenuated human rotavirus vaccine, Rotarix in south Indian infants. METHOD: Healthy infants (N=90), six to seven weeks of age were enrolled to receive three doses (n=45) or five doses of Rotarix vaccine (n=45) along with other scheduled vaccines, each dose separated by a four week interval. Blood samples were taken before vaccination and one month post-dose three in the Rotarix three dose group and one month post-dose five in the Rotarix five dose group; all were tested for anti-rotavirus IgA by an antibody sandwich enzyme immunoassay. RESULTS: At baseline, >50% of infants had >20 units of anti-rotavirus IgA. The seroconversion rates after three and five doses were low and not significantly different in the two groups. However, among vaccine responders, children seropositive at baseline showed a much greater absolute increase in IgA antibody levels than children seronegative at baseline. CONCLUSIONS: Rotarix vaccine showed low immunogenicity in south Indian children and increasing the number of doses did not increase the proportion of infants seroconverting after vaccination.
Authors: Venkata Raghava Mohan; Ramanujam Karthikeyan; Sudhir Babji; Monica McGrath; Sanjaya Shrestha; Jasmin Shrestha; Estomih Mdumah; Caroline Amour; Amidou Samie; Emanuel Nyathi; Rashidul Haque; Shahida Qureshi; Pablo Peñataro Yori; Aldo A M Lima; Ladaporn Bodhidatta; Erling Svensen; Pascal Bessong; Tahmeed Ahmed; Jessica C Seidman; Anita K M Zaidi; Margaret N Kosek; Richard L Guerrant; Jean Gratz; James A Platts-Mills; Dennis R Lang; Michael Gottlieb; Eric R Houpt; Gagandeep Kang Journal: J Infect Dis Date: 2017-08-01 Impact factor: 5.226